Compound Kugan Wet Mixture Fumigation Treatment Of Acute Damp Type Of Eczema Clinical Observation And In Vitro Antibacterial Test

OBJECTIVE: To observe the clinical curative effect of compound bitter Gan mixturewetdressing treating damp heat typeof perianal eczema, preliminary study of compound bitterGan mixture of each component in the mixture of drug and separately for the bacteriostaticeffect of Staphylococcus aureus.METHODS:.1: clinical observation: anorectal Department of the second hospital affiliated to AnhuiUniversity of traditional Chinese medicine hospital and outpatient, selected60cases metthe inclusion criteria of patients as the experimental case. In the selection of cases andpacket follow a random distribution law and the60cases were divided into treatment groupand control group, two groups were30cases. In the control group,3%boric acid solution tofumigation and wet compress, sooner or later each time, continuous use for a week. Thetreatment group was given compound bitter Gan mixture decoction after taking decoction tofumigation and wet compress, every time15minutes, sooner or later each time, the wholecourse of treatment using a package and a week of continuous use every day. Records ofthe treatment third, seven days EASI integral and TCM syndrome integral, carries on thestatistical analysis to the. And make a comparative analysis of recurrence three months aftertreatment in two groups.2: the bacteriostatic test in vitro: in accordance with the relevant standards for liquid dilutionmethod in vitro tests of Staphylococcus aureus were observed, Radix SophoraeFlavescentis, Radix Glycyrrhizae, pepper, phellodendron bark, dried alum and composed ofa prodrug compound sensitivity to Staphylococcus aureus and inhibitory effect. RESULT:.1: Clinical observation results:1.1From the total curative effect,60cases of damp heat type acute perianal eczema, ofwhich30cases of treatment group,30cases in the control group, comparative differenceafter treatment for reducing EASI total score value, the product difference has significance(p<0.05).Symptoms of EASI scores were1.2in treatment group and control group respectivelybefore and after treatment, two groups in the clinical symptoms were observed before thetreatment is extremely significant improvement (p<0.01).1.3In the treatment group and the control group third and seventh days after treatment, inthe control of pruritus and lesion area, reduction of EASI integral role in treatment groupthan in control group (p<0.05).1.4The observation of treatment group in improving the damp heat syndrome of syndromeis significantly better than the control group (p<0.05).Make a comparative analysis of recurrence1.5to two groups of three months of treatment,the relapse rate in treatment group was significantly lower than the control group (p<0.05).Results2in vitro antibacterial testExperiment shows that the compound bitter Gan mixture component drugs and mixed friedliquid have good inhibitory effect on the standard strains of Staphylococcus aureus, and theeffect was significantly enhanced after mixing liquid.Conclusion:(1) the compound Sophora Gan mixture using fumigation methods of wet apply on damp heat type acute eczema have the exact effect, compared with boric acid group, caneffectively reduce EASI and TCM syndrome integral, improve patient discomfort.(2) the compound Sophora Gan mixture with boric acid group contrast can better control therecurrence, long-term effect is good.(3) the compound Sophora Gan mixture application does not have obvious toxic side effect,has good safety, can be widely used in clinical.(4) the compound Sophora Gan mixture composition of the herbs and mixed decoction hasgood effect on Staphylococcus aureus...