Non-Motor Symptoms In Patients With Parkinson’ Disease Correlations With TNFα、IL-6、sIL-2R、hsCRP In Serum

Background:Parkinson’s disease(PD),also known paralysis agitans,is the secondmost common diseases of the central nervous system.In1817,fist described by theBritish physician James Parkinson, in the elderly is a common movementdisorders.The pathological features of PD are that dopaminergic neuronaldegeneration and loss and Louis corpuscle forming. Clinical manifestations of restingtremor, bradykinesia, muscle rigidity and gait abnormalities.65years of age or olderpopulation prevalence of2%. Currently, the number of Parkinson’s patients in Chinahas more than2million. Parkinson’s disease patients brought great distress to theirnormal life and brought a heavy to their family. In the past190years, the motorsymptoms of PD is always the key point of the research, with the in-depthunderstanding of PD disease, non-motor symptoms(such as:fatigue,emotionaldisturbance,sleep disorders and anxiety symptoms) gradually get people’s attention.Non-motor symptoms to patients suffering brought more durable, but people withParkinson’s non-motor symptoms of patients pathophysiology is not well understood.Objective:1.Respectively UPDRS, Webster, Fatigue Scale-14Fatigue Scale, HRSDAnxiety Scale, HRSD Depression Scale, NMSS, MOCA,the Pittsburgh Sleep QualityIndex scale of the disease and non-motor symptoms in PD patients evaluated.2.By detecting inflammatory substances(TNF-α、IL-6、sIL-2R、hsCRP)of peripheral to explore TNF-α、IL-6、 sIL-2R、hsCRP relationship with fatigue,anxiety, depression, sleep disorders between the role of research and development occurring in non-motor symptoms of Parkinson’s disease, investigate the pathogenesisof non-motor symptoms, prevention and treatment of non-motor symptoms ofParkinson’s disease provide new ideas.3.Proposed a view that mechanism may be involved in immuneinflammatory non-motor symptoms of PD.Research methods: Patients with idiopathic PD cases from the group inDecember2012,May2013in Dalian city center hospital(in accordance with the1992British PD Brain Bank diagnostic criteria of idiopathic PD). Select the control groupat the hospital during that time period and show physical health of people. Case groupinclusion criteria:Age:40-75years,the clinical diagnosis of Parkinson’s disease andaccompanied by non-motor symptoms, all patients signed informed consent.Thehealthy control group was randomly physical health in healthy older people agedbetween the ages of45-75.Exclusion of cerebrovascular disease, encephalitis ofcerebrovascular disease, encephalitis and other reasons caused parkinsonism.Exclusion criteria were applied to the patient and control groups.Respectively PDgroup UPDRS、Webster、NMSS Scale/HRSD Depression Scale, the Pittsburgh SleepQuality Index,MOCA scale assessment and olfactory detection of healthy controlgroup NMSS scale,Fatigue Scale-14,HRSD anxiety Scale,HRSD depression Scale,the Pittsburgh sleep Quality index scale, MOCA scale evaluation.Detection of PDpatients and healthy controls serum TNF-α,IL-6,sIL-2R,hs-CRP leves.Results:1.PD patients HRSD Anxiety Scale,HRSD Depression Scale,NMSS, thePittsburgh Sleep Quality Index Scale, Fatigue Scale-14fatigue scores weresignificantly higher than the healthy control group,and there are significantdifferences.MOCA scores were no significant differences. MOCA scores were nosignificant differences between the two groups.2.Most PD patients have varying degrees of olfactory damage.3.the significant difference between PD patients and healthy control groupwith TNFα、IL-6、hsCRP leves.4.Positive correlation relationship is between sIL-2R and depression、anxietysymptoms. hsCRP is negatively related to the anxiety and depression. Conclusion:1.Non-motorsymptoms of PD patients with complex and severe impacton the quality of life of patients.2.The onset and development of PD may be associated withinflammation.3.Inflammatory cytokines sIL-2R may participate in the PD of anxietyand depression symptoms in patients with occurrence and development.