| 1. Clinical analysis of48cases of chronic pancreatitisObjective: To provide clinical experience for the future diagnosis&treatment ofchronic pancreatitis (CP), we analyzed clinical data, diagnosis&treatment of48casesof CP.&summarized the clinical features of CP patients in our center.Method: Retrospective analysis of clinical data of48cases of CP who were admittedat the First Affiliated Hospital of Dalian Medical University from March2011to March2014. According to the data of general information, causative factors, clinicalmanifestations, major complications, laboratory tests, imaging studies and treatment ofthe CP, the constituent ratios were calculated.Result:(1) Age of onset for48cases of CP are placed between25years to89years,mean age (60.85±13.36) years with27males and21females, the gender ratio being1.3:1.(2) Occupational distribution showed the officers and staff accounted for14.6%,6.3%of workers,&farmers accounted for2.1%.(3) Duration of illness for≥1year in23patients,<1year in23cases, accounting for50%respectively, the average durationof illness of (6.48±9.44) years.(4) Causative factor included biliary disease in22cases(45.8%), hyperlipidemia in17cases (35.4%), alcohol accounted for16cases (33.3%), &smoking accounted for15cases (31.3%).(5) The main clinical manifestationsincluded abdominal pain in43cases (89.6%), weight loss in20cases (41.7%),abdominal distension in16cases (33.3%), and radiating pain in13cases (27.1%).(6)Major complications included diabetes in19cases (39.6%), pancreatic calcification&pancreatic duct stones in10cases (20.8%), pseudocyst in5cases (10.4%), andsteatorrhea in2cases (4.2%).(7) Laboratory tests on admission showed increased levelsof lipase (LPS), blood sugar (GLU), and serum amylase (AMY), but decreased levels ofhigh-density lipoprotein cholesterol (HDL-c). LPS increased in27cases (56.3%), GLUincreased20cases (41.7%), AMY elevated in13cases (27.1%),&HDL-c lowered in17cases (35.4%).(8) Regarding imaging,6cases (12.5%) underwent B-modeultrasound&four cases were diagnosed with CP;38cases (79.2%) underwent CTexamination&32cases were diagnosed with CP;21cases (43.8%) underwent MRI/MRCP examination&17cases were diagnosed with CP;2cases (4.2%) underwentendoscopic retrograde cholangiopancreatography (ERCP) examination&one casediagnosed with CP.(9) Among48cases,42underwent medical treatment (87.5%),5underwent endoscopic treatment (10.4%) and1underwent surgical treatment (2.1%).2. Relationship between blood lipid levels and chronicpancreatitisObjective: To explore the relationship between blood lipid levels and chronicpancreatitis (CP), we compared the total cholesterol (TC), triglycerides (TG),low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol(HDL-c) between the48cases of CP and healthy individuals.Method: Review summary from March2011to March2014at the First AffiliatedHospital of Dalian Medical University, comparison of serum lipids, gender, age,smoking&alcohol consumption between48cases of CP&randomly selected20healthy volunteers were statistically analyzed. Results:(1) Compared with the NC group, CP group had decreased HDL-c levels (P<0.01), but the TC, TG and LDL-c levels showed no significant difference (P>0.05).(2)Pearson correlation analysis showed that serum amylase (AMY) and LDL-c (r=0.414,P <0.05) were positively correlated, besides, urine amylase (UAMY) and TC (r=0.614,P <0.01), LDL-c (r=0.678, P <0.01) were positively correlated.(3) After adjustinggender, age, smoking and drinking factors, binary logistic regression analysis showedthat HDL-c is a protective factor of CP (OR=0.852, P <0.01).Conclusion:(1)①Biliary diseases were the main causes of CP in our hospital,followed by hyperlipidemia and chronic alcoholism.②CP patients admitted to ourhospital showed increased levels of LPS, GLU and AMY, but decreased levels ofHDL-c.③CT and MRI/MRCP were the most common imaging modalities used forthe CP diagnosis in our hospital.④Medical therapy was the mainstay of managing CPpatients in our hospital while the endoscopic therapy is still in its initial stage ofdevelopment.(2)①In CP group, HDL-c levels were significantly lower than the NC group.②AMYand LDL-c levels were positively correlated. UAMY with TC, LDL-c levels werepositively correlated.③HDL-c is a protective factor for the CP. |
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