The Correlation Between T Helper Type17Cells And Clinical Characters In Chinese Paediatric Patients With Chronic Hepatitis B

Hepatitis B virus (HBV) infection is a serious healthy problem. Approximately400million people worldwide are hepatitis B virus carriers, of which10%‐20%will develop into cirrhosis and1%to5%into liver failure. China is hepatitis B virus highly infection‐prone area with about93million hepatitis B virus carriers, and nearly90%of them get infected during the infant or childhood. Once infected with HBV, the virus will begin to interact with the immune system of human body. A large quantity of literatures suggest that immune response is essential for viral clearance, but the HBV nonspecific immune factors will cause damage to liver.CD4+T cells may provide cofactors and induce a cytotoxic T cell generation, thus play an important role in the pathogenesis of hepatitis B. In recent years, a group of new CD4+T cells were suggested to be unlike traditional Th1, Th2cells and can secrete large amounts of IL‐17as pro‐inflammatory cells. IL‐17has played an important role in autoimmune diseases, allergic diseases and infectious diseases. Studies have shown that highconcentration of IL‐17was foundinthe livers ofpatients with chronic hepatitis B,which wasassociated with liver damage. In addition, IL‐17facilitates liver inflammationbymodulating the generation ofgranulocyte,inducing cells to relaseproinflammatoryfactors, and initiating the mobilization of neutrophils. However, the pathologicaleffectof IL‐17uponchronic hepatitis B in adolescentsis less fullyinvestigated.Objective: Toanalyze the relevance betweenclinical indicatorsand the frequency of Th17cells detectedin the peripheral blood of children with CHB, thus toexplorethe anti‐infectioussignificance ofTh17cells in the body’s immunityof adolecences.