Clinical Study Of Four Extra Meridian For The Ovulatory Disorder In Polycystic Ovary Syndrome By Acupuncture Treatment

Object: To objectively evaluate the clinical effects to the patients with the ovulatorydisorder in Polycystic Ovary Syndrome (PCOS) by acupuncturing four extra meridianthrough observation and contrast with control, preliminary exploration of itsmechanism.Method: According to the inclusion criteria to select the cases,60patients with theovulatory disorder in PCOS were randomly divided into he treatment group (30cases)and the control one (30cases) by lottery. The treatment group was given the therapycombining acupuncturing four extra meridian with the oral western medicineclomiphene citrate. And the control group was simply used the oral western medicineclomiphene citrate. Analysis all datum and evaluating the effect by statistics after3courses of treatment.Result:(1) The total effective rate of the treatment group was93.33％, and the controlgroup is80.00％after the treatment. There were significant differences in the twogroups (P＜0.05). It’s inferred that the curative effect of the treatment group is betterthan the control one.(2) The comparison was significant differences in both before and after therapyin TCM total symptom score(P＜0.01). It’s inferred that the two groups can improvethe TCM total symptom score. After the treatment, there were more significantdifferences among two groups (P＜0.01), It’s inferred that the treatment group isbetter than the control one. (3) In posttreatment there were significant differences in treatment group aboutthe serum gonadal hormone (P＜0.05). Contrast to luteinizing hormone (LH), LH/follicle stimulating hormone (FSH) after the therapy, there were significantdifferences in control group. The treatment had more significant differences than thecontrol for the serum gonadal hormone (P＜0.05). It’s inferred that the treatmentgroup is better than the control one for the serum gonadal hormone.(4) After treatment, the rate of normal menstrual cycle in treatment group is91.76％and in control one is94.25％, the rate of normal menstrual flow in treatmentone is87.06％and in control is58.62％. There were more significance between bothof groups in menstrual cycle and volumen both before and after therapy (P＜0.05).It’s inferred that the two groups can improve the menstrual cycle and the menstrualflow. The treatment group had more significant differences than the control inmenstrual flow (P＜0.01), but there were no significant differences between2groupsin menstrual cycle after treatment (P＞0.05). It’s inferred that the two groups were nodifference in menstrual cycle, but in menstrual flow the treatment group is better thanthe control one.(5) After treatment, the Basal Body Temperature(BBT) in treatment group was86.25％and in control one was67.86％. Compared BBT cases after treatment, thedifference in two groups was statistically significant (P＜0.01). It’s inferred that thetwo groups can improved the BBT cases, but the improving effect on the treatmentgroup is better than than control one.(6) There were significant difference at endometrial thickness, the largest folliclediameter, the situation of follicular development and ovulation in two groups inpretherapy and post-treatment (P＜0.05). It’s inferred that the two groups canimproved the endometrial thickness, the largest follicle diameter, the situation offollicular development and ovulation. The treatment group had more significantdifferences than the control in the largest follicle diameter and situation of ovulation(P＜0.05), however, there were no significant differences in the endometrial thicknessand situation of follicular development among the groups (P＞0.05). It’s inferred thatthe two groups were no difference in endometrial thickness and situation of follicular development, but in largest follicle diameter and situation of ovulation the treatmentgroup is better than the control one.(7) After therapy, there were17patients in treatment group have pregnancyrequires and8patients become pregnant, pregnancy rate is47.06％. there were19patients in control group have pregnancy requires and3patients become pregnant, thepregnancy rate is15.79％. There was statistically significant in both (P＜0.05). It’sinferred that the two groups can improved pregnancy, but the treatment group is moreeffective than the control, the treatment group have higher pregnancy rate than thecontrol one.Conclusion: The study shows that both of therapies can refine the clinical symptom,sign and biochemical indicators of the patients with PCOS, but total effective rate ofthe treatment group is higher than the control. According to compared the serumgonadal hormone levels and color doppler ultrasound results of patients, the treatmentgroup is more effective than the control in refining the endocrine, endometrium,follicular development and ovulation. The treatment group is also better than thecontrol in refining the TCM syndrome, menstrual condition and gestation. All in all,the result point out that this method might have certain effect to treat the ovulatorydisorder in PCOS and it can be used in clinic. In this study, pinprick four extrameridian to treated the ovulatory disorder in PCOS, the mechanism is this treatmentcan regulate the physiological function of the “hypothalamic-pituitary-ovarian-womb”axis, causing the positive regulation to endocrine by hypothalamic, improvemicro-environmenr of the local ovarian, and promote the growth of follicles, promptea mature follicle rupture and induced ovulation.