| Background Diabetic nephropathy (DN) is one of the serious complications of diabetes, which could lead by microvascular disease, early clinical symptoms of patients with microalbuminuria, and then develop into renal failure, which is the major cause of death. TCM theory holds that the pathogenesis of DN is mainly related to the spleen does not clear up, no kidney essence, congestion block, stopping about the toxic cloud. Western medicine-related research indicates that blood glucose and lipid metabolism and the body’s micro-inflammatory state is an independent risk factor for early DN. While,high blood sugar, high cholesterol, increased blood viscosity and so on can be classified as congestion block, wet muddy. Huang Kui Capsule is extracted from yellow hollyhock flower, which has a function of anti-inflammatory, improving blood viscosity and correcting the dyslipidemia. Therefore, this article will research the effect of Huang Kui Capsule on blood glucose, blood lipids, renal function, and24-hour urinary albuminand micro-inflammatory state of DN patients, and to explore its application and mechanism,and to provide new ideas, new methods for the clinical treatment of DN.Purpose To investigate the effecton of Huang Kui microinflammation joint capsule Western conventional treatment on diabetic nephropathy (DN) patients,by Glucose, lipids, renal function,24-hour urinary albumin, micro-inflammatory state and hemodynamic effects,, analyze the mechanism of Huang Kui Capsule treatment of DN, which effectively controls DN patients with disease progression, delaying renal failure, and improve the quality of life of patients.Method Reference to the2005" Integrative diabetes diagnostic criteria " and the2002" Chinese medicine clinical research guidelines (Trial)" selected84cases of DN III-IV patients for the study, based on a random number table, patients were divided into observation group and control each group42cases, two groups of patients were diabetic diet management, aggressive treatment of diabetes, fasting blood glucose level control (<7.0mol/L) and postprandial glucose levels (<11.1mmol/L), while giving the patient glucose lowering pressure treatment. Observed group were given on the basis of Huang Kui Capsule treatment,5/time,3times/day, half an hour after meals oral, sustained medication eight weeks. The clinical efficacy of the two groups of patients, blood glucose, blood lipids, renal function, micro-inflammatory state and hemodynamic improvement after treatment.Results1.two groups of patients before treatment FPG,2hPBG were no significant difference (P>0.05), after treatment the observed group FPG,2hPBG were significantly lower than the control group, the difference was statistically significant (P<0.05).2.two groups of patients before treatment, TC, TG, HDL-C and LDL-C were no significant difference (P>0.05), after treatment the observed group TC, TG, LDL-C levels were significantly lower than the control group, while HDL-C levels were significantly higher, the difference was statistically significant (P<0.05).3.two groups of patients before treatment, BUN, blood Scr were no significant difference (P>0.05), after treatment the observed group BUN, blood Scr were significantly lower than the control group, the difference was statistically significant (P<0.05).4. two groups of patients before treatment,24-hour urinary albumin and urine red blood cells were no significant difference (P>0.05), after treatment the observed group24-hour urinary albumin and urine red blood cells were significantly lower than the control group, the difference was statistically significant (P<0.05).5.Two groups of patients before treatment, CRP, IL-2and TNF-α levels were no statistically significant (P>0.05), after treatment the observed group CRP, IL-2and TNF-α levels were significantly lower than the control group, the difference statistically significant (P<0.05). 6. Two groups of patients before treatment, ESR, Fb, nbl and nbh levels were no statistically significant (P>0.05), after treatment the observed group ESR, Fb, nbl and nbh levels levels were significantly lower than the control group, the difference statistically significant (P<0.05).7.After the intervention group was observed physiological function, bodily pain, general health, physical function, social function, role emotional, mental health, energy and other aspects of quality of life scores were significantly higher, the difference was statistically significant (P<0.05).8^in the observation group had one case of dizziness, nausea there are three cases, there is one case of loss of appetite, withdrawal symptoms disappear, adverse reaction rate was14.71%in the control group2cases of dizziness, nausea one case, a cases of anorexia, adverse reactions was11.76%, the rate of adverse reactions patients were no significant differences (χ2=0.985, P=0.326).Conclusions Huang Kui Capsule can effectively reduce the DN patients24-hour urine albumin, improve lipid levels, and effectively protect kidney function. |
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