Study The Relationship Between The50-year-old Adult Blood Lipids And Blood Glucose With Famine Exposure Based On The Medical Examination

Objective To examine total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol,and fasting blood glucose at the age of50famine exposure during fetal life,explorethe effect of the nutrition at the early stage on the adult diseases. Methods Take acluster sample of4252adults who were born in1957~1963from hospital physicalexamination center. The research object will be divided into three groups according tothe date of birth.983adults born in1957~1958are before the famine exposure group;1247adults born in1959~1961are famine set; and2022adults born in1962~1963areafter the famine exposed group. Compare the difference and the change trend of LDLcholesterol, HDL cholesterol, triglycerides，total cholesterol and fasting plasma glucosebetween these three groups. Results Subjects born in different years have statisticallysignificance (p<0.05~p<0.01) on total cholesterol, triglycerides, HDL cholesterol, andLDL cholesterol difference, and fasting plasma glucose differences have no statisticalsignificance (p>0.05). Male born in different years have statistically significance ontriglycerides levels(p<0.01). The highest concentration of triglycerides is that bornin1960. Female born in different years have statistically significance on totalcholesterol, triglycerides, LDL cholesterol, HDL cholesterol and fasting plasmaglucose(p<0.05~p<0.01). Males the before famine exposure group and famine set havelower triglycerides than after the famine exposed group.(P<0.01~P<0.05). And femalesof famine before exposure group have higher fasting blood glucose, total cholesteroland LDL cholesterol than famine set and after the famine exposed group(p<0.05~p<0.01). Conclusions Famine exposure in the earlystage may affect theblood lipid, the effect on the female after50years may be more significant than male. Itis important for the pregnant women having the balanced nutrition to prevent thechildren from chronic metabolic disease after they grow up. Objective To evaluate the liver and kidney function index level famine exposure in theearly stage, explore the possibility of using the liver and kidney function index asbiomarkers to evaluate the intrauterine organ development, verify metabolic"programmed" changes. Methods To take a random sample Cluster sampling in anhuiprovince in2011a large level of first-class hospital physical examination center, wasborn in1957-1963, physical examination,4258. According to the time of birth will bethe research object is divided into three groups, respectively, was born in1957-1958group; Born in1959-1961; Born in1962-1963. Born group for famine in1959-1961,1957-1958, was born to the famine before exposure group,1962-1963, was born to thefamine after exposure group; Through comparing analysis of variance between groupsAST, ALT, r-GGT, differences in the levels of SCr, UA, UREA and the changetrend.Results Different years birth research object ALT, SCr, UREA differences statisticallysignificant (p<0.05); Different years was born male ALT, r-GGT, AST, SCr differencesstatistically significant (p<0.05); Different years was born female AST, SCr, UA, UREAdifferences statistically significant (p<0.05); Between different famine groupspancreatic r-GGT, SCr, UREA differences statistically significant (p<0.05). Was born in1961groups of men ALT, AST is highest, the rest of the liver and kidney functionindexes has a tendency to change with age. Conclusions Famine exposure may have thedifferencent effect on liver and kidney function to different gender.