Analysis Of Clinical Characteristics Of158Lung Cancer Diagnosed By Fibrobronchoscopy Under The Age Of45

Background and Objective: In recent years,an increasing number of young patientswho are under the45years of age have been suffering from lung cancer. Thesepatients are easily misdiagnosed. We retrospectively analyzed the fibrobronchoscopydata of158young lung cancer patients enrolled in the First Affiliated Hospital of DalianMedical University in order to raise the awareness of youth lung cancer and explore theclinical characteristics of youth lung cancer.Methods: We selected158patients（outpatient and hospitalized）under the age of45who have been diagnosed by fibrobronchoscopy in the First Affiliated Hospital ofDalian Medical University between January2005and December2013. These patientsare confirmed by pathology. We collect their age, sex, smoking history, clinicalmanifestation, imaging findings, preliminary diagnosis, pathological type, diseasedregion, and the signs under the fibrobronchoscopy etc.Results: There were96male patients and62females patients.Our hospital158patientsunder the age of45have been diagnosed by fiberobronchoscopy, the first diagnosis oflung cancer were106,52patients the first diagnosis is benign lung diseases such astuberculosis or inflammation, but ultimately pathology confirmed lung cancer. Theratio of male to female was1.55. There were only3cases under the age of30yearslung cancer and accounted for1.9%.31-40years of age accounted for37.3%.41-45years of age accounted for60.8%. In the158cases, the percentage of adenocarcinomaaccounted for32.9%, which was significantly higher than other types of lung cancer.The percentage of squamous cell carcinoma was31.0%in all the data. The percentageof small cell lung cancer was29.8%in all the data. It was not obviously different thatthe percentage of adenocarcinoma in all the data was compared with squamous cellcarcinoma and small cell lung cancer (P>0.05).The percentage of squamous cell carcinoma in male (41.7%) was more than in female (14.5%). And the percentage ofadenocarcinoma in female (45.2%) was more than in male (25.0%).It was obviouslydifferent on the distribution of cancer histopathology type between male and female(P＜0.05). The ratio of small cell lung cancer in male accounted for29.2%, femaleaccounted for30.6%. It was not obviously different on the distribution of cancerhistopathology type between male and female (P＞0.05). The location of lung cancerwas likely followed by left superior, right superior, left inferior, right middle, rightinferior, left main, right intermediate, right main, main trachea. The squamous cellcarcinoma，adenocarcinoma and small cell lung cancer located more frequently in theupper lobe than lower lobe．Among158young lung cancer patients, bronchoscopyshowed84.2%had direct signs of lung cancer, and15.8%had indirect signs of lungcancer. The appearance of squamous cell carcinoma was mainly proliferative (65.3%),infiltrative was24.5%. There were obviously different (P＜0.05).The appearance ofadenocarcinoma carcinoma was mainly infiltrative (44.2%), proliferative was28.9%.There were obviously different (P＜0.05). The appearance of small cell lung cancer wasmainly proliferative (46.8%), infiltrative is42.6%. There were not obviously different(P＞0.05).Conclusion:.1. This study showed that adenocarcinoma was significantly higher than other types oflung cancer for the patients under the age of45years who have suffer from lungcancer and diagnosed by fiberbronchoscope. But compared with squamous cellcarcinoma and small cell cancer, there was not different obviously.2. The lung cancer located more frequently in the upper lobe for the patients under theage of45who have suffered from lung cancer and diagnosed by fiberbronchoscope.Pulmonary tuberculosis is also like to occuer in this place. When young patient hasproblem in the upper lobe, in addition to the benign disease should be taken intoconsideration, we also should have pay attention to lung cancer. These patientscould be diagnosed by fibrobronchoscopy.3. Different histological types of lung cancer has different features under the fibrobrochoscopy for the patients under the age of45who have suffer from lung cancerand diagnosed by fiberbronchoscope.4. This study suggests fibrobrochoscopy is an important approach in diagnosis of younglung cancer. Paying more attention to the lung cancer of young patients andexamining with fibrobronchoscopy would be helpful to earlier diagnose in order toreduce the missed diagnosis of lung cancer to young people.