| Background and Objective:In recent years, the incidence of lung cancerincreased year by year,to become a major disease hazard to human health.We retrospectively analyzed the fiber bronchoscopy data of814lung cancerpatients enrolled in the First Affiliated Hospital of Dalian Medical University, analyzethe relationship among age,sex,pathologic types, the sign under fiber bronchoscope andlocation,in order to explore the evaluation of fiber bronchoscopy in diagnosis of lungcancer. Analysis the108cases with immunohistochemical examination to explore theevaluation of distinguishing between the SCLC and SCC、adenocarcinoma.Methods:Fiber bronchoscope data of814lung cancer patients diagnosed byhistopathology or/and cell were detected by fiber bronchoscope from November2010to November2013, were analyzed retrospectively，（outpatient and hospitalized），Wecollect their age, sex, imaging findings, pathological type, diseased region, and thesigns under the fiber bronchoscopy，immunohistochemistry. Medical statistic analysisby SPSS17.0.Results:The features of814cases of definite lung cancer were squamous cellcarcinoma(SCC)(348),adenocarcinoma(149), small cell carcinoma(218),the rest ofpathological types were called other types, include non-small cell cancer(91) lowdifferentiated carcinoma（3）adenosquamous carcinoma(2) alveolar cell carcinoma(1)adenoid cystic carcinoma(1) pulmonary large cell neuroendocrine carcinoma（LCNEC）（1）,apparently,the squamous cell carcinoma was the most common of pathologicaltype.The male/female ratio was630:184.The most common pathological type wassquamous cell carcinoma, followed by small cell carcinoma and adenocarcinoma in630male patients.The percent of small cell carcinoma and adenocarcinoma was parallelon the whole,the percent of small cell carcinoma was higher slightly(37.5%69/184) in184female patients,the percent of adenocarcinoma was31.5%(58/184).50-69years old is the age of the higher incidence of lung cancer,the proportion was66.0%（537/814),followed by70-89years old（172/814）, most of the pathological type wassquamous cell carcinoma （230/53742.8%）（92/172,53.5%）.The ratio of30-49yearsold was12.8%(104/814),most of the pathological type wasadenocarcinoma(32/104,30.8%)，the ratio of small cell carcinoma and squamous cellcarcinoma were26.9%（28/104）、25.0%（26/104） respectively.Under the fiberbronchoscopy,the percent of infiltration was more than others（425/81452.2%）.TheAdenocarcinoma was more than the other in the infiltration,the ratio was29.2%（124/425）,followed by small cell carcinoma and squamous,the ratio was28.0%（119/425）、27.5%（117/425）respectively. Squamous cell carcinoma was more thanthe others in the proliferation,the ratio was66.8%（147/220）,followed by small cellcarcinoma，the ratio was16.8%(37/220). The major locations are as follows: leftsuperior、left inferior、right superior、left main、right inferior, most of pathologicaltype of left main was small cell carcinoma, the other locations were squamous cellcarcinoma.The number of the trachea and/or carina was involved was57，the ratio was7.0%（57/814）.In the108cases with immunohistochemical examination，the positiverates of CD56(NK-1) and TTF-1in the SCLC tissues were high（68/68）、（50/62）.TheCK5/6、p63expression was more frequent in squamous cell carcinoma,with sensitivityof84.6%（11/13）、76.9%（10/13）respectively.CK7expression was more frequent inadenocarcinoma with sensitivity of70.8%（17/24）.The positive rates of CK8/18inadenocarcinoma tissues were high（8/11).Conclusion:1.The fiber bronchoscopy is an effective way to diagnose lung cancer.For patientswith suspected lung cancer,especially in patients,With central lung cancer,as soon aspossible fiberoptic bronchoscopy.2.In this group of medical research,the pathological type of squamous cellcarcinoma was more common, with a significant difference were compared with smallcell carcinoma and adenocarcinoma.the rate of squamous cell carcinoma for men wassignificantly higher than women,the adenocarcinoma and small cell carcinoma forwomen was higher than men.3.In this group of medical research,50-69years old is the age of the higher incidence of lung cancer,followed by70-89years old, most of the pathological typewas squamous cell carcinoma with a significant difference.The pathological type of30-49years old was adenocarcinoma,but there was no significant differences.4.Under the fiber bronchoscope, different types have different findings.In thisgroup of medical research, infiltrative type was more common than proliferative.Thepathological type of proliferative was mainly squamous cell carcinoma,the pathologicaltype of infiltrative was mainly adenocarcinoma.5.The major locations are as follows: left superior、left inferior、right superior、left main、right inferior.Most of the pathological type of left main was small cellcarcinoma, the other locations were squamous cell carcinoma.6.CD56is a stable protein markers expressed by SCLC, CK5/6、PD63can be usedas markers SCLC and SCC differential diagnosis.The positive rates of TTF-1in theSCLC tissues were higher，the positive rates of CK7、CK8/18in the adenocarcinomatissues were higher. |
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