| Objective: Lung cancer is still a major health problem and is the most common malignancy-related cause of death in the world.Central lung cancer accounts for about 3/4 of lung cancer,the vast majority of patients were found in the late,this time often lost the best treatment time.The high mortality rate and low survival rate of lung cancer are closely related to whether they can be found early.White light bronchoscopy(WLB)is one of the most important means of detection of respiratory diseases and has been widely used in clinical practice.It has a very important role in the diagnosis and staging of lung cancer.However,the discovery of the pre-lesion showed insufficient.With the rapid development of optics and computer science,the emergence of autofluorescence bronchoscopy(AFB)makes up for the lack of common white bronchoscopy;its use of bronchial mucosa normal tissue and abnormal(cancer)between the different fluorescence Attribute to determine whether the abnormal mucosal cells to guide the biopsy to determine the pathological properties;usually normal tissue showed green,abnormal tissue showed red.At present,there are many studies on the diagnosis of pulmonary cancer in the diagnosis of lung cancer,and it shows that it has certain advantages;but whether the current autofluorescence bronchoscopy can be used in routine practice to improve the diagnosis of lung cancer and precancerous lesions the rate is still inconclusive.This study focused on the clinical application of autofluorescence bronchoscopy in the early diagnosis of central lung cancer.Methods :Selected from December 2015 to February 2017 in our hospital bronchoscopy room,chest X-ray or CT examination suspected central lung cancer,and according to the inclusion of a total of 184 patients were included in the white light(WLB)state And fluorescence(AFB)state of the synchronization check,the two abnormalities in the microscope were biopsy,brush and lavage examination,and access to the specimens sent to our hospital pathological examination.The sensitivity and specificity of AFB and WLB in the diagnosis of central lung cancer were compared according to the microscopic findings and pathological results.Results: Included in 184 patients,the final 105 cases were confirmed to be positive for pathology,79 patients with pathologically confirmed negative.AFB and WLB sensitivity of central type of lung cancer were 94.3(99/105),88.6%(93/105)(P> 0.05);specificity was 63.3%(50/79),41.8%(33/79)(P <0.05).Subgroup analysis,new biological group,the sensitivity of AFB and WLB to the diagnosis of central lung cancer was 91.1%(51/56),89.7%(52/58)(P> 0.05).Abnormal mucosa,The sensitivity of AFB and WLB to the diagnosis of central lung cancer was 67.9%(38/56),50.6%(41/81)(P <0.05).AFB and WLB II,III were compared.Group II,the sensitivity of AFB and WLB to the diagnosis of central lung cancer was 72%(36/50),50.6%(41/81)(P <0.05).Group III,the sensitivity of AFB and WLB to the diagnosis of central lung cancer was 80.8%(63/78),89.7%(52/58)(P> 0.05).Conclusion:1,In patients with airway visible biological growth in new no significant differences in sensitivity between the two inspection AFB and WLB.2,Higher airway mucosal abnormalities(ie,manifestations of hyperemia,edema,hypertrophy,hyperplasia)sensitivity in patients with AFB than the WLB.3,In patients with AFB and WLB microscopic level II group,higher than the sensitivity of AFB WLB respectively in the airway mucosa.4,AFB and WLB,respectively,in patients with stage III endoscopic group,no significant difference in sensitivity between AFB and WLB in the airway mucosa.5,The specificity of AFB in patients with high risk of lung cancer and imaging suspected central lung cancer is higher than that of WLB.AFB in the early diagnosis of central lung cancer has a certain clinical value. |
