Explore The Relationship Between Lipid Metabolism Disorder, Insulin Secretion In T2DM And Insulin Resistance

ObjectiveType2diabetes mellitus (T2DM) on glucose metabolism disorders often mergelipid metabolic disorder at the same time.This study mainly discusses lipid metabolicdisturbance of insulin secretion and insulin resistance in type2diabetes of the influenceas to provide theoretical basis for further lipid-lowering treatment of T2DM.MethodSelection in June2012to October2013yanan university affiliated hospitalendocrinology and dongguan branch comprehensive internal medicine,131cases of type2diabetes patients in hospital, according to whether or not it with blood lipid disorderswere divided into normal blood lipids group (57cases) and group (74cases), lipidmetabolism disorder in the lipid metabolism disorder group depending on thecomposition of the lipid metabolism disorder were divided into high blood triglycerides(TG) subgroups (Ⅰ group,30cases), high blood cholesterol (TC) subgroups (subgroupⅡ,21cases) and mixed hyperlipidemia subgroups (subgroup Ⅲ,23cases, high TGcombined high TC disease patient)。For the selected group of hospitalized patients withtype2diabetes in history, including the understanding of the patient’s medical history,medication; Human body measurements including height, weight, waist circumference(W), hip circumference (H) and blood pressure, and calculate the body mass index (BMI)and waist-to-hip ratio (WHR). And take time to abdominal venous blood fasting bloodglucose (FPG), blood lipid measurement series, glycosylated hemoglobin (HbAlc) ineach period, OGTT1hours to3hours blood glucose and venous blood biochemicalindicators such as level of insulin (FINS). To the degree of insulin resistance and isletbeta cells secrete a function by using the steady state model assessment method (homeostasis model assessment, HOMA) to evaluate, sugar load after islet beta cellssecrete a function to choose lee beta cells insulin secretion index to evaluate.Measurement data with mean±standard deviation, study subjects can be divided intoblood lipids and blood lipid disorder group mean differences between the two groupswhen compare to choose independent sample t-test, mean differences between the threegroups and three sets of the above comparison of application of the single factor analysisof variance, the inspection level by α=0.05, P<0.05, said data difference is statisticallysignificant.Results1. Each test group had no significant difference in the age, sex, systolic pressure,diastolic blood pressure, body mass index and waist-hip ratio;2. Compared with blood lipids group, blood lipid disorder group (combination for agroup of sanya) in patients with HOMA-IR, HOMA-is reduced, the difference wasstatistically significant; Lipid metabolism disorder of sanya high TG levels, and thegroup and mixed hyperlipidemia group compared with normal group, HOMA-IR highblood TC subgroups and mixed hyperlipidemia group compared with normal groupHOMA-is reduced, the difference was statistically significant; High TG group, high TCgroup and mixed hyperlipidemia group among three groups of HOMA-IR, HOMA-,MBCI, P>0.05, there was no statistically significant difference; Blood lipids and bloodlipid disorders between sanya and sanya group compared MBCI index, P>0.05, there wasno statistically significant difference.3. Compared with Blood lipid disorders and blood lipids group, fasting blood glucose,the difference was statistically significant; Two groups of glycosylated hemoglobin,fasting insulin, c-peptide, P>0.05, there was no statistically significant difference.4. Lipid metabolism disorder in patients with T2DM the dyslipidemia characteristicsfor dyslipidemia group of TG, TC, LDL is not elevated blood lipid disorder group, HDLdecreased, P<0.01, the difference was statistically significant; High TG group and mixedhyperlipidemia in patients with higher HDL lower TC group, P<0.05, the difference wasstatistically significant; High TC group and mixed hyperlipidemia in patients with higherLDL, TG group (P<0.05, the difference was statistically significant. 5. In blood lipid metabolic disorder group TG was nversely associated withHOMA-IR, MBCI were positively correlated, r value of r=0.614, respectively, r=0.427,P <0.01); Subgroups in group dyslipidemia Ⅰ and subgroup Ⅲ TG wasnverselyassociated with HOMA-IR, MBCI were positively correlated, r value of r=0.722,respectively, r=0.609, P <0.01); Subgroups of Ⅲ TG wasnversely associated, withHOMA-IR, MBCI were positively correlated, r value of r=0.802respectively r=0.799(P <0.01); TG blood lipid disorders in the group with fasting insulin, fasting glucose,glycosylated hemoglobin were positively correlated, r value of r=0.595, respectively, r=0.414, r=0.252(P <0.05).6. In blood lipid metabolic disorder group TG was nversely associated withHOMA-IR, MBCI no correlation, negative correlation with HOMA–, r value of r=0.266(P=0.022<0.05); And glycosylated hemoglobin were positively correlated, rvalue of r=0.322, P <0.01).Conclusion1. Lipid metabolism disorder can increase insulin resistance and islet beta cellssecrete a function obstacle in T2DM patients.2. High TG levels, to a certain extent, can reflect the severity of the patients with type2diabetes insulin resistance.3. High blood TC can be increased in patients with type2diabetes islet beta cellssecrete a function obstacle.4. Patients with type2diabetes and lipid metabolism disorder when the blood fat ischaracterized by higher TG, TC, LDL, HDL, high TG levels, often accompanied by lowHDL levels, high TC hematic disease associated with elevated LDL.