The Change Of Tube Structure And The Complications Of Transmigration Process After Replacement With The Nitinol Artificial Esophagus

Objective: The valuable animal experimental model data and theoretical basis wereprovided for further consummated manufacture of nitinol artificial esophagus in vivoand future using in clinic by observing the effect of the change of tube structure andthe complications of transmigration process in vivo for organsim after replacementwith the nitinol artificial esophagus.Methods: There are12experimental pigs models underwent replaced withtypeⅠ/Ⅱ n itinol artificial esophagus on operation. After operation the pigs weredivided2groups (group Ⅰa ndgroupⅡ) accordance with the type Ⅰ/Ⅱn itinolartificial esophagus. There are6pigs each group. After operation the pigs were feedby feeding regulation measures to control time of artificial esophagus slipped. Onepig of each group implanted artificial esophagus fixed in situ was sacrificed fordissection followed2,4,6months postoperative and the change of tub structure wasobservation. The remaining6pigs were observation as the nitinol artificial esophagusslipped for arrival place of the nitinol artificial esophagus slipped, the tube structure,the transmigration process and the complications of transmigration process. Theexperimental data was statistical analysed for percentage (%).Results：There are not died for operation in12pigs. When two sets implantedartificialesophagus were fixed in situ follow2,4,6postoperative, there are the changes of tubestructure was observation in2,4,6month postoperative. The silicagel membranatectoria cochleae were wearing at amphi-tube. furthermore the wearing of silica gelmembrana tectoria cochleae was more severity in six months postoperative than four months postoperative and in four months postoperative than in two months. Therewere not any complications. All of the remaining6pigs the implanted artificialesophagus slipped to stomach range from4to6months postoperative. In groupⅠ theslipped artificial esophagus of3pigs were discharged by intestinal tract after2to3months of nitinol artificial esophagus slipped and there were not any complicationsof digestive tract.(for example: bleeding of digestive tract, perforation of digestivetract, obstruction of digestive tract) Two of the discharged tube structure were intacand one was break in tube structure. In group Ⅱ the slippedartificial esophagusstayed in stomach from6months to8months and there are not any complications ofdigestive tract (for example bleeding of digestive tract, perforation of digestive tract,obstruction of digestive tract) and dysphagia except one pig dead of pyloricobstruction because slipped artificial esophagus blocked up pylori.Conclusion: When the nitinol artificial esophagus fixed in situ the polyesterconnecting ring and tube structure of the nitinol artificial esophagus had notbreaked.The silica gel membrana tectoria cochleae were weared at amphi-tube. The more longstay time was, the more severity the wearing of the silica gel membrana tectoriacochleae was. But the silica gel membrana tectoria cochleae in tube body had notweared obviously; When the nitinol artificial esophagus slipped from esophagus tostomach the type Ⅰt ube was more breakable than the type Ⅱ tube underacidenvironment. The typeⅠ tube was more easy to pass throughpylori and eliminate outof body from the intestine than the type Ⅱt ube. The type Ⅱt ube was easy toblock uppylori resulting in pyloric obstruction than the type Ⅰt ube.