Changes Of Serum Levels Of Interleukin-10、-13、-15in Children With Henoch-schonlein Purpura And Its Clinical Significance

Objective To analyse the changes of serum levels of interleukin-10，-13，-15andpartial immunological indexes in acute phase and convalescence，including some cases withrenal involvement and anothers without renal involvement in acute phase，in children withHenoch-Schonlein purpura (HSP), discuss the correlation among these indicators andinvestigate their clinical significance．Methods According to the diagnostic criteria for HSP as defined by ‘Zhu Fu TangPractical Pediatrics’7th Edition, forty children with HSP hospitalized from Sep.2010to May2011were selected as subjects of the acute phase group,including19cases with renalinvolvement and21cases without renal involvement.The same40children were used assubjects of the convalescence group after treated with regular treatment for about two weeksand the symptoms such as skin rash, abdominal pain and joint swelling pain disappeared.Twenty healthy children were selected as healthy control group. The levels of IL-10，IL-13and IL-15were measured by double antibody sandwich enzyme-linked immunosorbent assay(SELISA) and C-reactive protein by rate nephelometry. The data were analyzed by SPSS17.0software.Results1．The acute phase serum levels of IL-10，IL-13，IL-15and CRP in HSPchildren were significantly higher than that of the convalescence group and healthy controls(P<0.01and P<0.05)；when convalescent serum level of these indicators were compared withthat of healthy controls, only IL-13was significantly higher (P <0.05)，while no significantdifferences of IL-10，IL-15or c-reactive protein existed (P>0.05)；2．There was significantcorrelation between acute phase serum levels of IL-10，IL-13, IL-15and CRP in HSP children. 3．IL–10，–13，–15levels with renal involvement were significantly higher than that ofwithout renal involvement (P <0.05)； IgA in HSP children significantly higher than that ofcontrol group，and IgA levels with renal involvement were significantly higher than that ofwithout renal involvement (P <0.05)；IL–10，–13，–15and IgA obvious correlation by thecorrelation analysis．Conclusions Serum IL-10，IL-13，IL-15involved in the occurrence and development ofHSP； The changes of IgA and CRP are related to the changes of IL–10，IL–13，IL–15inserum of children with henoch-schonlein purpura．...