Research On Key Technologies Of Central Aortic Pressure Reconstruction And System Based On Two Peripheral Pressure Waves

Central Aortic Pressure (CAP) is an independent predictor of cardiovascular diseases to theperipheral pressure. It is also a key determinant of the degenerative changes and hypertension.The study of CAP measurement is thus of great interest and arouses worldwide concern. The“Gold standard” is that a micromanometer is advanced inside the lumen of pigtail catheter placedin the ascending aorta. However, this method will bring about pain and risk.Previous studies have shown CAP can be reconstructed from peripheral hemodynamicinformation by the means of radial-aortic transfer function or forward-backward pressure wavedecomposition. However, the method of radial-aortic transfer function cannot differentiateindividual CAP accurately whilst the latter method required additional blood flow measurementto reconstruct an accurate CAP wave. In this study, we proposed a novel method based on twoperipheral arterial blood pressure waves to reconstruct CAP. We first analyzed the mechanism offorward-backward pressure wave decomposition and carried on the theoretical derivation.According to the forward-backward pressure wave decomposition method, we obtained a newmathematical model for CAP reconstruction. The new theory was then simulated by arterialblood pressure waves downloaded from PhysioNet (a free web-based resource for the study ofphysiologic signals). We second built the system using both volume clamp method andtonometry method for measuring continuous blood pressure simultaneously from finger andradial artery. Third, the new theory was confirmed by collecting real patients’ data and weanalyzed errors with effected elements. Finally, we promote new solution optimize the newalgorithm in the future.