Alcoholic Liver Disease Complicated By Cholestasis In Combination Therapy Studies

Objective:alcoholic liver disease is one of cholestatic liver disease etiology, less domestic and foreign cholestasis research for alcoholic liver disease complicated by reports, which Professor Laurent Spahr et al[1] found that alcoholic steatohepatitis died concurrent cholestasis a high rate, prognosis and treatment are not yet ripe. According to Professor O’Shea et al [2] reported that about25%of chronic alcoholic liver disease with intrahepatic cholestasis, and often indicates a poor prognosis.Therefore, the present study was to Capital Medical University, Beijing Ditan Hospital,88patients admitted to hospital with alcoholic liver disease complicated by cholestasis collate clinical data were retrospectively analyzed to understand the treatment and prognosis of alcoholic cholestatic liver disease, and to explore alcoholic cholestatic liver disease pathogenesis and diagnosis and treatment of traditional Chinese medicine.Methods:1Received medical records live in alcoholic liver disease admissions inspection subsidiary Beijing Ditan Hospital, Capital Medical University from January2008to December2013period, according to the2010alcoholic liver disease treatment guidelines and in2013the diagnosis and treatment of cholestatic liver disease expert consensus be the inclusion and exclusion of qualified medical records collected88cases.2Use EpiData3.1history data management software records the patient, physical examination, laboratory tests, imaging studies, patients with traditional Chinese medicine tongue and pulse records, TCM and herbs.3According to the survey data analysis (1) alcoholic liver disease complicated by the patient’s clinical features of cholestasis;(2) alcoholic liver disease complicated by cholestasis prognosis and contrast the differences in the efficacy of the combination therapy group and western medicine;(3) alcoholic liver disease complicated by cholestasis TCM symptoms and syndrome differentiation characteristics of patients.4Statistical Methods:Using a variety of methods SPSS21.0statistical software for statistical analysis to bilateral P<0.05as statistically significant.Results:1. Prognosis:Child rated as alcoholic liver disease complicated by cholestasis independent prognostic factors.2. Alcoholic liver disease complicated by cholestasis Integrative no statistically significant difference in treatment group and western medicine group. 3. TCM symptoms and syndrome differentiation characteristics:TCM can be divided into gallbladder damp heat, toxic heat flaming, wet storm stomach, Hanning Yang failure, liver qi stagnation, Qi and Yin injury six types. Multi-use detoxification, heat, cooling, phlegm, dampness, righting the traditional Chinese medicine, such as law.Conclusion:Through the study of88cases of alcoholic liver disease in patients with concurrent deposition of bile medical records found:1disease in male patients significantly more than female patients. Age of onset in patients between the ages of40to59maximum. Drink only species to drink liquor based. Average daily alcohol consumption in the80-160g majority, drinking more time is about20years and30years.2baseline biochemical indicators showed that compared with normal reference values, the patient total bilirubin, direct bilirubin, alkaline phosphatase, γ-glutamyl transferase levels were significantly elevated albumin levels were significantly lower, ALT, AST levels are quite different in different patients.388patients died during hospitalization in6patients, the overall mortality rate was6.82%, four cases of gastrointestinal bleeding,12cases of hepatic encephalopathy (4deaths),3cases of hepatorenal syndrome (of which2deaths).4patients with gastrointestinal bleeding due to timely treatment and generally better not die.4. Child score can become an independent prognostic factor plays an important role in an assessment of the mortality of the disease.5. Medicine for alcoholic cholestatic jaundice considered to belong to the wine category, excessive alcohol, complex sense of evils, as occurred wine diet Laojuan common cause of jaundice. Overall pathogenesis damp stagnation, organs deficiency. TCM:can be divided into damp, hot toxic stasis, spleen wet storm Ⅳ, after we found the liver qi stagnation, Qi and Yin injury of two types, the use of detoxification, heat on traditional Chinese medicine in the medical records, cooling blood, phlegm, dampness, etc. righting law. Because of the relatively small number of patients with the treatment of drug targets, did not reach statistical significance. So the next step will be to study this disease prospective, randomized, double-blind, multi-center trials of drugs to improve these shortcomings of the study.