| Objects:To observe the clinical efficacy and symptoms efficacy of PCOS by the experience prescription--yishenzhuyanghuoxuehuazhuotang of Chai Songyan, a famous old doctor of traditional Chinese medicine. To research the change of Testosterone (T),Luteotropic hormone (LH),Luteotropic hormone (LH)/Follicle Stimulating Hormone (FSH),and Estradiol (E2).Methods:With method of randomized parallel-control,32patients of PCOS with kidney qi deficiency and spleen deficiency with phlegm wet were divided into the research group and the control group. The research group:18patients were treated with yishenzhuyanghuoxuehuazhuotang. The control group:14patients were treated with Ethinylestradiol Cyproterone Acetate Tablets. Respectively compare general effect and traditional Chinese medical effect at3and6months’treatment. The ovarian volume, the number of ovarian follicle and the size of follicle diameter were tested and the serum testosterone (T), luteinizing hormone (LH), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and estradiol (E2) levels were monitored by vagina or rectum B ultrasonic.Results:Comprehensive effect analysis of the research group:the total effective rate was83.33%, the clinical cure rate was22.22%, the clinical significant effect rate was44.44%,the clinical effective rate was16.67%, no clinical effect rate was16.67%. Comprehensive effect analysis of the control group:the total effective rate was77.57%, the clinical cure rate was14.29%, the clinical significant effect rate was28.57%,the clinical effective rate was28.57%, no clinical effect rate was22.43%. The total effective rate of the research group and the control group has significant difference (P<0.05). We can see that the integrated effect of the reseach group was better than the control group. The TCM syndromes of the research and the control group:the TCM syndrome score before and after the treatment of the research group has a significant difference (P<0.01), the TCM syndrome score before and after the treatment of the control group has a significant difference (P<0.05). The TCM syndrome scores were lower before treatment of the researchgroup and the control group. The two groups had significant differences (P<0.01) after treatment. So after treatment, the symptom scores of the research and control groups were lower, and there were significant differences between the two groups of decline,. The improvement of the TCM syndrome efficacy of the research group was better than the control group. The B ultrasonic of research and the control group after treatment, the B ultrasonic score of the research and control group had significant difference (P<0.05) before treatment. There was a significant difference (P<0.01) of the control group before and after the treatment, so the B ultrasonic score were lower than before treatment of the two groups. There was no significant difference between the two groups in B ultrasonic score(P>0.05). So, after treatment, the B ultrasonic score of the research and the control group were lower, and the decline of the control group was greater than the research group, but with no significant difference between the two groups of decline. The BMI of the research and the control group after treatment:the BMI of the research group before and after treatment has significant difference (P<0.05). The BMI of the research group was lower before treatment. The BMI of the control group had no significant difference before and after treatment.(P>0.05). The BMI of the control group was lower before treatment, but with no significant difference. The BMI of the two groups had no significant difference (P>0.05) after treatment. So after the treatment, the BMI were lower in research and control group. The decrease in the research group was greater than in the control group, but there was no significant difference between the two groups after treatment. The serum T levels after3and6months’treatment:the serum T levels in the research group after treatment was significantly lower before treatment, there was a significant difference (P <0.01) compared before treatment. The serum T levels in the control group after treatment was significantly lower before treatment, there was a significant difference (P<0.05) compared before treatment. The serum T levels after treatment had no significant difference (P>0.05). So the serum T levels after treatment of the two groups were significantly lower before treatment, but serum T levels in both groups had no significant difference after treatment. The serum LH levels at3and6month of treatment of the research and control group, the serum LH levels in the research group after treatment was lower before treatment, there was a significant difference (P<0.05) compared before treatment. The serum LH levels in the control group after treatment was significantly lower before treatment, there was a very significant difference (P<0.01) compared before treatment. The serum LH levels after treatment of the two groups had no significant difference after treatment. So after the treatment, the serum LH levels were lower in research and control group after treatment. but there was no significant difference between the two groups after treatment. The LH/FSH at3and6month of treatment of the research and control group, the LH/FSH in the research group after treatment was lower before treatment, there was a very significant difference (P<0.01). The LH/FSH in the control group after treatment was significantly lower before treatment, there was a very significant difference (P<0.01) compared before treatment. The LH/FSH after treatment of the two groups had no significant difference after treatment(P>0.05). So after the treatment, the LH/FSH were obviously lower in research and control group after treatment. but there was no significant difference between the two groups after treatment. The serum E2levels at3and6month of treatment of the research and control group, the serum E2levels in the research group after treatment had no difference before treatment, there was no significant difference (P>0.05) compared before treatment. The serum E2levels in the control group after treatment was significantly lower before treatment, there was a very significant difference (P<0.05) compared before treatment. The serum E2levels after treatment of the two groups had no significant difference after treatment (P>0.05). So after the treatment, the serum E2levels had no difference in research group but decreased in control group, but there was no difference between the two groups after treatment.Conclusion:PCOS of kidney qi deficiency and spleen deficiency with phlegm wet treated by Chai Songyan’s yishenzhuyanghuoxuehuazhuotang was more effective than treated with Ethinylestradiol Cyproterone Acetate Tablets. Yishenzhuyanghuoxuehuazhuotang and Ethinylestradiol Cyproterone Acetate Tablets can both improve the clinic symptoms of PCOS of kidney qi deficiency and spleen deficiency with phlegm wet and the polycysticovarian status, and also reduce ovarian volume. In thephysical and chemical indicators, both of them can effectively reduce serumtestosterone(T), luteinizinghormone(LH) and LH/FSH, and Yishenzhuyanghuoxuehuazhuotang a was better than Ethinylestradiol Cyproterone Acetate Tablets in improvement of clinic symptom and lower androgen... |
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