Pulmonary Fibrosis TCM Syndrome Characteristics And Correlation With HRCT In

Pulmonary Fibrosis(PF) is a common outcome of a variety of Interstitial Lung Diseases(ILD). It is difficult to be awared of and cured among all respiratory diseases.There is no special treatment except of lung transplantation.Drugs which used most in clinical are glucocorticoid and immunosuppressant,but it is reported that they often have side effects and seriously affect the the quality of patient’s life.There is no consistent understanding about the etiology,pathogenesis and treatment prescriptions, and it is lack of evidence of evidence-based medicine.So the research on treatment of PF is important in theoretical and clinical.Objective:Our aim is to provide a new thought on treatment by statistical analysis of patient data and conclude the peculiarity and law of the TCM symptoms.Methods:Patients who meet the criteria of PF was investigated by methods of clinical epidemiology,.We combined pulmonary function with imaging characteristics to classified diseases, SPSS was used to statistical data. We arranged and analyzed patients’data in order to conclude the peculiarity and law of the TCM symptoms.Results:(1)Most of patients were older than50years and in70-79age group.The incidence was similar between men and women. The average course was3.5years.Majority of patients had chronic diseases,for example, circulation system diseases,immune system diseases and respiratory system diseases.(2)The important influence factors of PF were smoking and dust exposure.(3)84.3%of the patients had cough symptom,the degree of cough was not heavy.88.6%of patients had sputum symptom, among which, white sputum was most commonly seen. Episodes of cough were irregular.(4)87.1%of the patients had shortness of breath symptom,this symptom often happens when walking uphill or brisk walking.74.3%of patients had symptoms of depressive feeling.(5)65.7%of the patients were intermingled deficiency and excess symptoms.Among deficiency syndromes, lung qi deficiency accounted for28.6%,lung kidney concurrent deficiency accounted for25.7%. Among excess syndromes,phlegm-damp syndrome accounted for40%.The course of PF which was short was prone to being excess syndrome. As time goes on,it was common to see combination of excess syndrome and deficiency syndrome. Patients of different ages had no obvious difference between excess syndrome and deficiency syndrome.(6)The disease mainly located in lung and related to the spleen and kidney. (7)The longer the course of disease was, the heavier the HRCT classification was, and symptom of shortness of breath was more obvious.In the early period of HRCT, there almost were excess syndrome, Phlegm-dampness and phlegm-heat were main reason.Deficiency syndrome was not common, it mainly referred to lung qi deficiency, lung yin deficiency.In the middle period of HRCT,the most common pattern of syndrome was intermingled deficiency and excess.Deficiency syndrome was mainly indicated to lung qi deficiency, and lung kidney deficiency appeared too in this phase.Among excess syndromes, phlegm-dampness and phlegm-heat, phlegm-stasis were increased than before.In the terminal stage of HRCT deficiency syndrome and intermingled deficiency and excess were most common. Deficiency syndrome was mainly for lung kidney concurrent deficiency, heart-kidney imbalance and kidney-yang deficiency. Excess syndrome was mainly for phlegm-dampness and phlegm-stasis.In the early period of HRCT, the lung was mainly involved.In the middle period of HRCT,lung and kidney were mainly involved.. Lung was still dominated. In end-stage of HRCT, lung and kidney were mainly involved.. kidney was dominated. There was no significant difference between cough, sputum and choking.Conclusion:(1)Pulmonary fibrosis was likely to occur in the old people and had no gender differences.Most patients were combined with basic chronic diseases. Smoking and dust exposure was one of the important factors affecting pulmonary fibrosis.(2) Major performance of patients was cough, sputum,shortness of breath and choking. The disease was located in the lung and referred to the spleen and kidney.Nature of disease was mainly intermingled deficiency and excess.Deficiency syndrome were almost lung qi deficiency, lung Yin deficiency and deficiency of lung and kidney.The main reason of excess symptom was phlegm-dampness and phlegm-stasis.(3)HRCT reflect how severity of the disease was.In the early period of HRCT, excess symptom was common,and deficiency syndrome which mainly referred to lung qi deficiency was less than excess one.The lung was mainly involved.In the middle period of HRCT lung and kidney were mainly involved.. Lung was still dominated. In the end-stage of HRCT, lung and kidney were mainly involved.,kidney was dominated.There was no significant difference between cough, sputum and choking.