The Clinical Research Of Sj(?)gren's Syndrome With Pulmonary Interstitial Fibrosis Treated By Chinese Medicine Prescription Named Yangyinshengjin Huoxuetongluo

Pulmonary fibrosis is an advanced manifestation of the interstitium disease caused by a variety of causes,which is chronic,progressive,fibrotic,and survives about 2-4 years in untreated patients.Sjogren's Syndrome-induced interstitial fibrosis is one of interstitial lung diseases secondary to immune disease,which refers to the progressive fibrosis interstitial lung caused by the primary disease-Sjogren's syndrome.The maincharacteristic is that the symptoms of Sjogren's syndrome coexist with the symptoms of the lungs.The most common feature of pulmonary histopathology and/or imaging is the nonspecific interstitial pneumonia.The current mechanism has not been clarified.Glucocorticoids and immunosuppressive agents were selected to cooperate with anti-fibrotic drugs.Due to the larger side effects,there were many restrictions on its application.In recent years,Chinese medicine has gradually increased its research in this field.Its understanding of the etiopathogenisis and pathogenesis have been gradually deepened.The traditional Chinese medicine are effective by many clinical reports.Objective:The purpose of this study was to investigate the effects of the Chinese medicine prescription named yangyinshengjin huoxuetongluo on the clinical symptoms,physical signs,laboratory-related indicators,pulse oximetry,and pulmonary function in patients with Sjogren's syndrome and pulmonary interstitial fibrosis.To objectively evaluate the therapeutic effects of Yangyinshengjin huoxuetongluo Fang on Sjogren's syndrome with pulmonary interstitial fibrosis.Methods:According to the principle of parallel open control trial,60 patients were divided into treatment group(n=30)and control group(n=30).Both groups were treated on the basis of hydroxychloroquine.The treatment group added yangyinshengjin huoxuetongluo decoction.The control group added Acetylcysteine Tablets.The course of treatment is 12 weeks.Put the 0 weeks(before treatment),4 weeks,12 weeks(after treatment)as the observation point.Observe the difference of symptom scores,sign,laboratory index,lung function,and pulse oximetry before and after treatment between two groups.At last,use the statistical software to process data.Results:The total effective rate was 83.33%and 36.67%respectively in the treatment group and the control group after different treatments.There was significant difference(P<0.05)in the treatment group between before and after treatment of the scores in the aspects of dry mouth,dry eyes,the levels of ESR,CRP,IgG(P<0.05),but no difference in the control group.There was significant difference(P<0.05)in both groups between before and after treatment of chest tightness and asthma,cough,fatigue and saliva flow,FEV1 and TLCO-sb.but the treatment group were better than the control group.There was no significant difference about the rate of tear flow between before and after treatment(P>0.05)between the two groups.The levels of static state finger-oxygen determination in both own group were significantly different(P<0.05)before and after the treatment,but no difference between them after treatment(P>0.05).Conclusion:The yangyinshengjin huoxuetongluo decoction treatment can significantly improve the patient's symptoms,improve some indicators,such as lung function,which is better than Acetylcysteine Tablets.