Study On Pharmacy For FuFang QinJie Capsule

Emergency, chronic infection of the upper respiratory tract is the commonchronical disease of spirt system in the clinic. So it is important to reinforce theprevention and curing for upper respiratory tract. This medicine is Extractedandrefined of baical skullcap root, Ephedrae, coptidis rhizome, Gardenia ect. It isconvenient and safe to use,so people enjoy accepting it.This thesis includes 6 parts:1 Overviewing the research procession of the FuFang QinJie Capsulefor Emergency, chronic infection of the upper respiratory tract。2 Identificatin of the FuFang QinJie medicine resources.The resources and qualities of the herbs in the FuFang Qinjie formula areidentified by Pro.Chen Jianwei, pharmacognosy department of Nanjing university oftraditional Chinese medicine.The medical materials of FuFang QinJie Capsule, suchas baical skullcap root, Ephedra herb, coptidis rhizoma, gardenia, cypsum fibrosum,fermented soybean, and amoorcorn tree bark are purchased from HeBei, HeBei,SiChun, ZeJiang, HuBei, DongBei, SiChun.All the Chinese medicine herbs meet therelevant criterion of Pharmacopoeia of People’s Republic of China English Edition2005.3 The conclution of produce technology.3.1 Determining content of alkaloid、jasminoidin which are effective elements of thedrug by orthogonal experiment. Chosen Orthogonal table L₁₈（3⁷） in the experimentof extracting in alcohol, to research the effect of content of alkaloid、jasminoidin fromtechnological parameters（example solvent-density, extraction times, the time ofextraction etc）. Through the analysis of the variance extraction times and the time ofextraction have significant effect on the content of alkaloid、jasminoidin in theexperiment of extracting in alcohol. The best producing technology as follows: adding15 times amount of 70％alcohol, decocting for 3 times, 2 hours each time.3.2 Determining content of calcium ion by orthogonal experiment. Chosen Orthogonal table L₉（3⁴） in the experiment of extracting in water, to research the effectof calcium ion content from technological parameters（example water volum,extraction times, the time of extraction etc）. Through the analysis of the variance thebest producing technology as follows: soaking 1 hour, adding 20 times amount,decocting for 3times, 1.5 hours each time.3.3 Determining content of ephedrine and baicalin by orthogonal experiment withHPLC spectrophotometer. Chosen Orthogonal table L₁₈ （3⁷） in the experiment ofextracting in water, to research the effect of ephedrine and baicalin content fromtechnological parameters（example water volum, extraction times, the time ofextraction etc）. Through the analysis of the variance the best producing technology asfollows: soaking 1 hour, adding 15 times amount, decocting for 2 times, 2 hours eachtime.3.4 Through comparing the various solvent-density alcohol precipitationtechnology, 70％alcohol is the best precipitation condition.The content of baicalinand ephedrina reduce obviously with 80％alcohol. As the solvent-density increase, thecontent of baicalin and ephedrina decrese.Comparing the 50％and 60％alcohol, thecontent of baicalin and ephedrina has no disparity. As the dosage considered, 70％alcohol is best.3.5 The study on the spray dryin and CONC technology mainly determining thecontent of alkaloid and baicalin. The consequence with TTEST manifest there is nodisparity between antero-CONC and retro- CONC. As the dosage considered, thebest CONC technology with 0.08Mpa, 60℃is best.The study on the spray dryin technology mainly determining the contentof alkaloid, baicalin and water content. The consequence with TTEST manifest thereis no disparity between antero- spray dryin and retro- spray dryin. As the dosageconsidered, the best spray dryin technology is: relative density of extracta sicca is1.10～1.15 （60℃）, blast temperaturelentrance 65～175℃, underpressure 300～350Pa, blast temperature debouch 85～90℃.3.6 The study on the capsule forming technology mainly determining thegranulating method.The capsule forming technology with 95％EtOH. The capsule filling technology with the No .0 caps. is best. All the finishedproduct meet the relevant criterion of Pharmacopoeia of People’s Republic of ChinaEnglish Edition 2005.According to the research consequence, establish the produce technology.4. By identifing coptidis rhizoma, gardenia, Ephedra herb, baical skullcap root withTLC technology, determining content of baicalin with HPLC technology, andmaking check for the capsule according to Pharmacopoeia of People’s Republic ofChina English Edition 2005, institute the quality criteria of Fufang Qinjie capsule.The HPLC determine content condition of Paeoniflorin as follow: C₁₈chromatographic column（200×4.6mm,i.d,5μm）;MeOH:H₂O:H3PO4 （47:53:0.2）;column temperature:25℃; flow rate:1.0ml/min;detect wave length:280mn; theoryplates（according to Paeoniflorin） must be not less than 2000.The technology of baicalin determination mainly includes system suitabilitytest, linear correlation investigation, stability test, precision test, reproducibilitytest,and application recovery test.The consequences manifest all above correspondwith the relevant criterion.5 Inspecting the stability for FuFang QinJie Capsule in room temperature6 Concluding the research above all.