Dispersing Blood Stasis Detoxification Method In Treatment Of Plasma Cell Mastitis Of Clinical Research

Objective：This study with TCM dspersing blood stasis detoxification method intreatment of plasma cell mastitis (liver by wind-cold type), observe the clinical curativeeffect; Venous blood and through external weeks Chinese super sensitive C-reactiveprotein, the T cells subgroup detection, study of plasma cell mastitis pathogenesis andmechanism of blood detoxification treatments for the disease.Methods: In clinical diagnosis of plasma cell mastitis (PCM) of63cases of patients,set as patient group, and were randomly divided into two groups, the treatment group35examples, giving dspersing blood stasis detoxification method28days (x) with externaltreatment of traditional Chinese medicine therapy;28cases in the control group,anaerobic bacteria resistant (ornidazole x14days) treated with external treatment inTCM.Observation group before treatment, treatment2weeks,4weeks in patients withclinical syndrome integral, and peripheral venous blood Chinese super sensitive C-reactive protein (Hs CRP) and T cells subgroup (CD3, CD4, CD8and CD4/CD8)changes; At the same time observe the control treatment, treatment2weeks before theclinical syndrome integral, and the above indexes, compared with group2weekstreatment. Chose12cases healthy female volunteers for health group, extraction ofperipheral venous blood to detect T cell subgroup compared with63cases of PCMpatients before treatment.Results：1. The clinical curative effect1.1symptoms integral:2weeks treatment, the treatment group significant symptoms integral is reduced,the difference was statistically significant (P <0.01); Control group lower earliersymptom integral, the difference was statistically significant (P <0.01). The symptomscore more similar between the two groups (P <0.01). Treatment group4weekstreatment, symptom integral compared with before treatment, treatment2weeks more obvious difference (P <0.01).1.2treatment effect:2weeks treatment, treatment group cure0cases,6cases were markedly improved(17.14%), effective in16cases (45.71%), invalid13cases (37.14%), the total effectiverate was62.86%; Control group cure0cases,4cases were markedly improved(14.29%),18cases (21.43%), invalid effective6cases (64.29%), the total effective rate35.71%, by chi-square test, the difference was statistically significant (P <0.05).Treatment group4weeks after treatment, to cure6patients (17.14%),20cases weremarkedly improved (57.14%), effective,8cases (22.86%), invalid in1case (2.86%),the total effective rate was97.14%.2. Immune to compare2.1abnormal situation:63patients before treatment, the normal reference value of the Hs-higher CRP in49cases (77.78%). CD3was abnormal in11(17.46%), and give priority to in order toincrease; CD4was abnormal in31(49.21%), and give priority to in order to reduce;CD8abnormal6cases (9.52%), give priority to in order to increase; CD4/CD8abnormal39cases (61.9%), give priority to in order to reduce.2.2TCS patients before treatment group compared with healthy group:CD3slightly higher than the healthy group, the difference had statisticalsignificance (P <0.05); CD8no difference (P>0.05); CD4, CD4/CD8is lower thanthe healthy group, the difference had statistical significance (P <0.05).2.3the treatment group and control way is:Treatment group: the Hs-CRP,2weeks and4weeks treatment were decreased,compared with before treatment, there was significant difference (P <0.01); CD4, CD,2weeks and4weeks treatment were higher than before treatment, compared with beforetreatment, the difference was statistically significant (P <0.05); CD3treatment2weeksis slightly lower, but compared with before treatment, statistical difference (P>0.05),and4weeks treatment compared with before treatment, the difference was statistically significant (P <0.05); CD82weeks and4weeks treatment, compared with beforetreatment, there were no significant differences (P>0.05).Control group: treatment2weeks, the Hs-CRP was reduced, the compared withbefore treatment, the difference was statistically significant (P <0.05); CD3, CD4, CD8and CD compared with before treatment, no significant difference (P>0.05).2.4comparison between treatment group and controlled way:2weeks treatment, two groups of Hs-compare CRP, big reduction in treatmentgroup than control group, but statistical difference (P>0.05),; Two groups of CD4comparison, the difference was statistically significant (P <0.05); Two groups of CD3and CD8and CD4/CD8(CD), there was no statistically significant difference (P>0.05).Conclusions：1. Dspersing blood stasis detoxification method of traditional Chinese medicinetreatment of liver by wind-cold type of plasma cell mastitis, has better clinical curativeeffect, worth clinical promotion2. Plasma cells sexual mastitis Hs-CRP in patients with a high reference value, theHs-CRP can be used as one of the laboratory indexes of observing the diseasecondition change.3. The CD3, CD4, CD4/CD8, is different compared with the healthy group can beconcluded that the disease may be related to T cell-mediated immune cells have acertain relationship.4. Adjust the body’s immune function, the likelihood is the traditional Chinesemedicine dspersing blood stasis detoxification method is one of the mechanism of thetreatment of plasma cell mastitis.