Correlation Of C-reactive Protein With Periodonta Disease And Coronary Heart Disease

Objective:CHD,also is referred as coronary heart disease, can be said that it impacts people’s health and quality of life now. Chronic periodontitis is an infection which slowly acts on periodontal tissue. It not only impacts on the local periodontal tissue of the human body, resulting in localized infection of human periodontal tissue, causing localized periodontal tissue structure, function injury, but also may trigger damage to various body systems (such as the cardiovascular system). Numerous studies have shown that there is potential outcome of contac between chronic periodontal disease and coronary heart disease, sharing similar risk factors such as smoking, hypertension, diabetes, obesity, blood lipids and so can be used as similar factors to promote and increase the prevalence of both diseases. Essentially, periodontitis and coronary heart disease which is the essence of this pathological inflammatory infections of the body tissue corresponding to the overall course of the disease is an inflammatory response, and inflammatory disease goes throughout the whole process; C-reactive protein is one extremely active and sensitive matter in inflammation reaction, and he may be closely correlated with the presence of both diseases. By studying the distribution of CRP in serum, and the relationship with serum and periodontal indexes, this paper explores certain correlation of CRP with both diseases, and the important roles that CRP played in the occurrence and development of the two diseases.Methods:1.research objectives:Select60cases that originally diagnosed as coronary heart disease in Shanxi Cardiovascular Hospital from September to December in2013, including30cases of coronary artery disease along with periodontitis (CP Group),30cases of coronary heart disease alone (group C);30cases of chronic periodontitis selected from the mouth clinics and medical centers of the Provincial People’s Hospital,, who were assigned to simple periodontitis group (P group),and30healthy swarm, who was assigned to the healthy control group (H group).2.clinical data collection2.1general routine inspectionsTake detailed records of all subjects, including the age, sex, height, weight, smoking history, previous history of hypertension, and the whole History of body systems and other projectsand so on. All enrolled patients must receive blood biochemical tests, fasting blood drawn, test results and related data registration documented. Specific registration results include:HDL-C, TC, LDL-C, Triglyceride (TG),Fasting plasma glucose(FPG), and White blood count(WBC).2.2oral specialist inspectionsInspect full-mouth periodontal of all subjects in detail, including full mouth dental six-point PD, SBI,and AL.2.3serum CRP inspectionsTake the morning fasting venous blood of all subjects, determinate serum hs-CRP by immunonephelometry and record.Results:1.The results of routine clinical indicatorsThere is no significant difference ingender, HDL, FPG among four groups (P>0.05). Serum WBCs in all disease groups were significantly higher than the healthy control group, andmeaningful statistical difference (P<0.05). Serum TC, TG, LDL in coronary heart disease associated with periodontitis group and in coronary heart disease group was obviously higher than that of pure periodontitis group and healthy group, and meaningful statistical difference (P<0.05).2.The analysis of periodontal indexThere were significant differences in the periodontal indexs (PD diagnosis depth, gingival sulcus bleeding index SBI, attachment loss AL) between four sets, and meaningful statistical difference (P<0.001). PD, SBI, AL in coronary artery disease associated with periodontitis and periodontitis group were significantly higher than CHD and healthy reference group, and meaningful statistical difference (P<0.05).3.The analysis of serum CRP concentrationThere were significant differences in serum CRP between four groups, and meaningful statistical difference (P<0.001). Of this, serum CRP in the coronary artery disease and periodontitis chronic periodontitis higher serum CRP group (P<0.05), chronic periodontitis group than in the CHD group (P<0.05), coronary heart disease than in healthy reference group (P<0.05).4.The correlation of clinical serological indexes and each periodontal indexThere were positive correlations between serum WBC and periodontal index (PD and SBI, AL), with the correlation coefficient r and P values were:r=0.500, P<0.001; R=0.521, P<0.001; R=0.555, P<0.001).5.The correlation of serum CRP and the periodontal indexesSerum CRP and periodontal index PD, SBI, AL are related, and are a positive correlation with the correlation coefficient r and P values were:r=0.500, P<0.001; R=0.635, P<0.001; R=0.702, P<0.001).6.The correlation of serum CRP and clinical serological indexesSerum CRP and WBC are related, and are a positive correlation, with the correlation coefficient r-0.500, P<0.001).Conclusion:1.Serum CRP levels in descending order are:coronary artery disease with the highest periodontitis, periodontitis group simply followed the CHD group again, minimum health groups. The results suggest that periodontal disease can lead to higher level of serum CRP, and induce the occurrence of coronary heart disease and impact its development in certain extent.2.CRP is correlated with both periodontal index and serum markers, and this shows that the occurrence and development of CRP and periodontitis and coronary heart disease are related, and CRP may be also related to the relationship between the two. With the increase of serum CRP level, periodontal index, the severity of periodontitis aggravate.