| IntroductionChronic periodontitis and coronary heart diseases (CHD) are two of the most popular diseases which do great harm to our health. For the past few years, there are a lot of epidemiologic studies in vitro and animal tests. Which indicated that chronic periodontitis is concerned with CHD and artherosclerosis (AS) . Periodontitis was indicated as an independent risk factor to CHD.The influence of chronic periodontitis as an independent risk factor to CHD may has a complicated mechanism, and cytokines play an important role in the mechanism. High sensitive C-reactive protein (hs-CRP) and interleukin-8 (IL-8) may be mesomerisms that can transfer the information between cells. It was confirmed that hs-CRP and IL-8 play a active role in the nosogenesis and development of CHD. They may participate the physio-act through the complic information transfer and then adjust the host immune function. With the co-control of other cytokines, they may cause the adherency and the accumulation of thrombocytic and may effect the function of vescular endothelial cell and then may accelerate and aggravate the patho-course of CHD. Meanwhile, with their anti-inflammatory function and inflammatory function, Hs-CRP and IL-8 play an active role in the nosogenesis of chronic periodontitis.After one month of therapy, subjects in the exp-group presented with lower gingival plaque scores, lower and lower numbers of PD when compared to control group one. Lower levels of hs-CRP of serum and GCF and IL-8 of serum were exhibited (P<0.05). The level of IL-8 of GCF didn't show the significant difference because a just major Further evidences of the relevance beCtween the two diseases were provided.Materials and methods40 chronic periodontal patients with CHD, the age between 40-75, were divided into two groups randomly. There are 25 patients in the exp-group receiving routine medical maintenance therapy (no antibiotic) and periodontal non-surgical treatment. The other fifteen patients as the control one, only receive routine medical maintenance therapy (no antibiotic). At the same time, fifteen chronic periodontal patients without CHD were collected as the control group two who received periodontal non-surgical treatment.The periodontal indexes in 3 groups were detected at the baseline and one month after the treatment or the first visit. The levels of hs-CRP (immunity tarbidimetry) and IL-8 (ELISA) of serum and GCF were measured in the patients for two times. The data was analyzed using SPSS11.5 software carries on statistic analysis.Experiment resultsThere is no difference in general condition and in the mean of periodontital infective index number among each group, the patients with chronic periodontitis and CHD exhibited higher levels of hs-CRP and IL-8 and higher mean of sulcular bleeding index (SBI) and probing depths(PD) when compared to control group two.After one month of therapy, subjects in the exp-group presented with lower gingival plaque scores, lower and lower numbers of PD when compared to control group one. Lower levels of hs-CRP of serum and GCF and IL-8 of serum were exhibited (P<0.05). The level of IL-8 of GCF didn't show the significant difference because a just major individual difference.We also observed a consistent positive correlation association between levels of hs-CRP and IL-8 of serum and clinical periodontal parameters (PD) (P<0.05). DisussionThe influence mechanisms between chronic periodontitis and CHD are still not very clear. There has a chance that the local inflammatory response to the pathogenic bacteria creates inflammatory factors, complex information is transfered by the factors. It is a complex system involving the interactions of leukocytes with active vascular endonthelial cells. The cellular homeostasis and the normal physiologic function are degraded so that the patho-course of CHD is accelerated and aggravated.The present experiment indicated that there was a high attack rate of medium to severe periodontitis among the CHD patients. The chance is related with the compliance of them. Under the identical general condition, there was a more severe inflammatory response in the patients with chronic periodontitis and CHD. The chance is that two chronic diseases influence each other and more inflammatory factors are created which accelerated and aggravate the course of both.The present experiment indicated that no matter CHD is complicated, marked improved effect of periodontal patients were observed after one month of therapy. Effects of the simple periodontitis patients are better than others. hs-CRP showed a marked more sensitive reactive than IL-8.ConclusionsUnder the identical general condition, there was a more severe inflammatory response in the patients with chronic periodontitis and CHD. Circulating levels of hs-CRP and IL-8 are influenced by local inflammation. Periodontal non-surgical treatment can decrease the levels of hs-CRP and IL-8and it may thus decrease their risk of CHD.
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