A Clinical Questionnaire And Systematic Review Of The Correlation Between Periodontal Disease And Coronary Heart Disease

ObjectiveThe aim of this study is done based on a self-compiled questionnaire and professional peridontal examination to detect the clinic status of dieffrent periodontal and CHD patients and to assess the correlation between periodontal disease and angiographically-defined coronary heart disease, providing a firm basis of the strategic prevention. The results may provide evidence of the correlation between CHD and PD.Method1.Clinical research: In case-control study, twenty-eight CHD Patients referred for diagnostic coronary angiography. Twenty-eight non-CHD cases passed the periodontal exmaination by the same physician were taken as conrtols respectly. The ratio of male and female was 18:10 in case group, which in control group was 17:11. All the cases were tested on the relational, moreover compared and analyzed the data accodring to different groups by SPSS13 software.2.Systematic review: We conducted a systematic review of the published literatures about the relationship of PD and CHD. However, adding one literature about the correlation between PD and CHD through the clinic study by myself. The data were analyzed by RevMan 4.2 software and SPSS13 software. Using the value of OR/RR and 95%CI as the assessmet of the the link between PD and CHD, then drawing the forest plot and funnel plot.3.Statistic analysis: The results were expressed as mean±stnadard deviation. Dieffrence in inflammatory marker levels among various subgroups and between visits were analysed by t-test and analysis of varinance. Chi-squared test was utilized to detemrine significant assoeiation among categorical variables. Significance was set at P<0.05.Results1. The prevalence of periodontal disease was 71.42% in CHD group, while 39.29% in control group. There were statistical significance in both group. Uni-analysis indicated that periodontal disease OR was 3.864(95%CI,1.265 to 11.805), cigarette smoking OR was 3.178 (95%CI,0.987 to 10.228), hypertension OR was 3.263(95%CI,1.089 to 9.776)and family history of cardiovascular disease OR was 3.882(95%CI,l.056 to 14.276) may be the risk factors of CHD. Multiple factorial Logistic regression analysis showed that besides hypertension, cigarette smoking and family history of cardiovascular disease and so on, periodontal disease was the variables in the equation. Significantly dosage-effective response was also found in the relationship between periodontal disease and CHD. The differences between case and control group were not statistically significant for GI and PLI. But people in CHD group considered they had poorer PI than that of the same age.2. According to the inclusion criteria and exclusion criteria, 14 studies were selected. Including 11 clinical controlled trails,OR was 2.23(95%CI,1.93 to 2.58) and 3 prospective cohort studies, RR was 1.40 (95%CI,1.28 to 1.54). All studies were tested for heterogeneityχ2=9.87, P=0.70>0.05.Fixed effect model analysis shows that the summary RR was 1.45 (95%CI,1.35 to 1.52), indicating a higher risk of future coronary heart disease in individuals with periodontal disease compared with those without.ConclusionThrough the results of a clinical questionnaire indicated that periodontal disease may be the risk factors of CHD; peirodontitis, especially severe periodontitis, significantly enhanced risk for CHD. Through systematic review analysis suggests that periodontal disease is significantly relates to coronary heart disease,they may be a risk indicator for each other. However,we should strengthen the prevention and cure of PD and control the probability of CHD .