Clinical Study Of Qi-boosting Blood-quickening Phlegm-Detoxizating Therapy On Sepsis

1ObjectiveTo observe the clinical therapeutic effects of qi-boosting blood-quickeningphlegm-detoxification therapy on sepsis with hot phlegm，gas deficiency and bloodstasis type by clinical study， and observe its influence on the acute physiology andchronic health evaluation Ⅱ (APACHE-Ⅱ score)，chinese medicine symptom integral，interleukin-1β(IL-1β)， complement C5a(C5a)， Amino terminal brain natriureticpeptide precursor (NT-proBNP)，hypersensitive C reactive protein (hs-CRP)，TroponinI (cTnI)， oxygenation index (OI)， lactic acid(LAC).We want to explore the possiblemechanisms of qi-Boosting blood-quickening phlegm-detoxification therapy onsepsis so it can provide objective basis for integrative medicine treatment of sepsis.2MethodsWe choose60patients diagnosed as sepsis in ICU in our hospital from January2013to December2013， they were randomly divided into two groups， control groupof30patients， the treatment group of30patients. The control group receivedConventional Western medicine treatment (Early fluid resuscitation, antibiotics,correcting water, electrolyte and acid-base balance disorders, nutritional support,oxygen, assisted respiration need to use a breathing machine, improve hemodynamics,improve coagulation status, immune conditioning and treatment of the primary disease,etc.)， the treatment group received qi-boosting blood-quickening phlegm-detoxification therapy (Shen Mai injection+Sodium Tanshinon ⅡAsilate injection+hot poisonous clear injection) on the basis of Conventional Western medicinetreatment，taking7days as one course of treatment. Before and after seven daystreatment， Patients were observed about changes of APACHE-Ⅱ score， chinesemedicine symptom integral， IL-1β， hs-CRP， NT-proBNP， cTnI， C5a，OI，LAC，and comparing clinical prognosis of the two groups. 3Results3.1The level of APACHE-Ⅱscore and chinese medicine symptom integral in thetreatment group decreased significantly after treatment， compared with the controlgroup was statistically significant (P <0.05).3.2In terms of Inflammatory response indicators， The level of IL-1βand hs-CRP in thetreatment group decreased significantly after treatment， compared with the controlgroup was statistically significant (P <0.05).3.3In terms of myocardial depression response indicators， The level of NT-proBNPand cTnI in the treatment group decreased significantly after treatment， compared withthe control group was statistically significant (P <0.05).3.4In terms of imbalance in the body immune reaction response indicators， The levelof complement C5a in the treatment group decreased significantly after treatment，compared with the control group was statistically significant (P <0.05).3.5The level of OI increased remarkably and the level of LAC decreased significantlyin the treatment group after treatment， compared with the control group wasstatistically significant (P <0.05).3.6In terms of prognostic outcome， treatment group was significantly better than thecontrol group， the two groups have a significant difference (P <0.05).4ConclusionQi-boosting blood-quickening phlegm-detoxificating Therapy on sepsis hasobvious clinical effect， can reduce the level of acute physiology and APACHE-Ⅱscore and chinese medicine symptom integra.Qi-boosting blood-quickening phlegm-detoxification Therapy achieved the purpose of treating disease and improving thepatient’s prognosis and outcome maybe through inhibiting excessive inflammatory response and inhibiting cytokine， improving myocardial inhibition，improvingsystemic oxygenation，and improving tissue perfusion and oxygen supply，. This study，no obvious adverse drug reactions， provides objective indicators for integrativemedicine treatment of sepsis and reflects the the characteristic of Chinese medicine.