Clinical Study Of Qi-boosting Blood-quickening Phlegm-dispersing Therapy On AECOPD With Respiratory Failure

Objective To survey the effects of qi-adding blood-quickening sputum- dispersing cure the AECOPD with Respiratory Failure and survey its impact on the APACHE-Ⅱscore、chinese medicine symptom points、pulmonary surfactant protein D(SP-D)、interleukin-8(IL-8)、hypersensitive C reactive protein(hs-CRP)、oxygenation index( OI) 、 blood gas analysis target(Pa CO2 、 Pa O2) 。 We want to probe the maybe mechanisation of qi-adding blood-quickening sputum-dispersing cure the AECOPD with Respiratory Failure,so it can offer the of objective and scientific basis for treatment of AECOPD with Respiratory Failure.methods We select 60 cases of patients as AECOPD with respiratory failureour in ICU in our hospital from 2013 August to 2014 Novembe,they were randomly divided into two groups,30 cases in the treatment group,30 cases in the collation group。The collation group accept common treatment of Western Medicine(including anti infection,mechanical ventilation,bronchodilator, sputum-dispersing,right electrolyte acid-base balance disorder,nutritional sustain,etc.),the treatment group accept the taditional chinese medicine of qi-adding blood-quickening sputum- dispersing(Shen Mai injection + Sodium Tanshinon Ⅱ Asilate injection +tanreqing injection to hot dispersing or keckuanping granules to hantan) on the foundatio of Common Western medicine treatment 。 The Change were observed before and after treatment in the patients of two groups of indicators:APACHE-Ⅱ score、 chinese medicine symptom points、pulmonary surfactant protein D(SP-D)、interleukin 8(IL-8)、high sensitive C reactive protein(hs-CRP)、oxygenation index(OI)、blood gas analysis(Pa CO2、Pa O2), and compare the clinical result of two groups of patients。Results3.1 The level of APACHE-Ⅱ score and chinese medicine symptom integral in the treatment group decreased significantly after treatment, compared with the control group was statistically significant(P<0.05).3.2 The level of SP-D score in the treatment group decreased significantly after treatment,compared with the control group was statistically significant(P<0.05).3.3 The level of IL-8 and hs-CRP in the treatment group decreased significantly after treatment, compared with the control group was statistically significant(P<0.05).3.4 In terms of blood gas analysis indicators,The level of Pa O2 and OI in the treatment group increased significantly after treatment, compared with the control group was statistically significant(P<0.05)。The level of Pa CO2 in the treatment group decreased significantly after treatment, compared with the control group was statistically significant(P<0.05).3.5 In terms of prognostic outcome,treatment group was significantly better than the control group, the two groups have a significant difference(P<0.05).Conclusion Qi-boosting blood-quickening phlegm-dispersing Therapy on AECOPD with Respiratory Failure has obvious clinical effect,can reduce the level of acute physiology and APACHE-Ⅱ score and chinese medicine symptom integral 。 Qi-boosting blood-quickening phlegm-dispersing Therapy achieved the purpose of treating disease and improving the patient’s prognosis and outcome maybe through inhibiting cytokine,improving systemic oxygenation,improving tissue perfusion,oxygen supply。This study, no obvious adverse drug reactions, so it can offer the of objective and scientific basis for treatment of AECOPD with Respiratory Failure.