The Prospective Research Of TCM Syndromers Of WD And Other Relative

Objectives:Discussion the hepatolenticular degeneration (Wilson’s disease, WD) of the common clinical syndromes as well as the relationship between gender, age, course of disease, clinical type, severity of disease classification by the large sample clinical prospective study, so that provide the basis for future reasonable clinical diagnosis and treatment.Methods:On the basis of literature research,"WD Chinese medicine dialectical table" were designed, data of TCM Syndromes of WD patients were collected. Syndrome differentiation was then applied to WD patients using the traditional Chinese medicine eight classes and viscera syndrome differentiation theory to establish a database of patients with WD. After that, the common syndromes of WD distribution, as well as the relationship between gender, age, course of disease, clinical types, severity classification were summarized using frequency analysis and chi square statistical analysis.Results:The clinical study of1043patients, including654male (62.70%),389female (37.30%), the female to male ratio is about1.68:1. The minimum age is6years old, the oldest is57years old, the average age is (19.71±10.14) years old. The cases of juvenile is456(43.72%), juvenile is367(35.19%), children is215(20.61%), middle age is5cases (0.48%). The incidence of WD in men is higher than women.The shortest duration of WD patients is7days, the longest is35years, mean duration of disease is (5.25±5.57) years. In376cases of1to5years (36.05%) is the most common, followed by the course from high to low for the357cases of6～10years (34.23%),11～15178cases (17.07%),16～2087cases (8.34%),20years in45cases (4.31%). Western medicine clinical type in399cases of brain type (38.26%) is the most common, followed by brain type in338cases (32.40%), visceral306in cases (29.34%).Grading of severity with grade Ⅲ339cases (32.51%) the most, followed by Ⅳ in305cases (29.24%),230cases of grade Ⅱ (22.05%), Ⅰ in169cases (16.20%).Grading of severity with grade Ⅲ339cases (32.51%) the most, followed by Ⅳ in305cases (29.24%),230cases of grade Ⅱ (22.05%), Ⅰ in169cases (16.20%). Through the studies in1043cases of WD patients clinical investigation, clinical syndrome patients mainly appears to lack of appetite (86.58%), abdominal pain (82.74%) with ribs, gum bleeding epistaxis (73.25%),(68.94%) limbs fibrillation, saliva droplets (61.46%), walking instability (61.17%), joint pain (60.79%), verbal Jian acerbity (49.57%). Seeing more, the rest of the syndrome are: heavy sensation in the limbs and body (44.77%), dry mouth, and (or) the sense of smell in the mouth (40.94%), body weight loss (36.05%), deep sign (36.05%), nausea and acid regurgitation(30.58%), lumbar acid cold (26.17%), back stiff (24.26%), fever in chestplams～soles(23.30%), erbianshitiao (22.15%), spontaneous perspiration and night sweating (21.76%), limbs spasm pain (20.90%), limb swelling (18.98%), irritability (17.16%), forgetfulness(16.78%), insomnia (13.71%), petechia (13.14%), intolerance of cold and cold limbs (13.14%), dizziness that upset balance (12.94%), difficulty falling asleep (11.89%), eyes sour and pain (10.26%), being down in spirits (or) depression (9.40%), yellow skin yellow eyes (9.30%), menstrual disorder (8.25%), lusterless complexion (7.29%), hematemesis and melema (6.52%), anaesthesia in the limbs (5.66%), palpitation (5.18%), abnormal behavior (4.13%), chest tightness, shortness of breath (3.93%), abnormal behavior (3.734%), skin color dark (3.73%), decreased libido (1.15%), tooth shakes send (1.05%), deafness tinnitus (0.83%). The clinical symptoms in patients show no significant difference between the male and the female (P>0.05). Conclusion:The proportion of patients with WD syndrome type distribution, with shireneiyun in221cases (21.19%), ganshenyinxu in168cases (16.11%), qixueliangxu in111cases (10.64%), ganfengneidong in108cases (10.35%),102cases (9.78%) of ganyupixu, tanshizuluo in101cases (9.68%) were more common, followed by ganshenbuzu in78cases (7.48%), pishenyangxu in70cases (6.71%), tanyuhujie in29cases (2.78%), qiyinliangxu in17cases (1.63%),15(1.44%) cases of tanhuoraoxin, tangmengxinqiao in12cases (1.15%),11cases (1.05%) of qizhixueyu.The WD syndrome type show no significant difference between the male and the female (P>0.05).The relationship between TCM syndrome type and age of onset, children see more ganshenbuzu(29.77%), ganshenbuzu(27.44%), shireneiyun(24.18%); adolescent syndrome appear more, not only the existence of ganshenyinxu, ganshenbuzu, ganyupixu, pishengyangxu, but also shireneiyun, ganfengneidong, tanyuhujie, tanyuzuluo, tanmengxinqiao, while middle～aged people show qixueliangxu(60%), ganshenyinxu (40%).The relationship between TCM syndrome type and the course of disease, shireneiyun, ganshenbuzu, ganshenyinxu in the early course was more prominent, in the middle course, the proportion of dampness resistance, qizhixueyu and tanyuhujie were gradually increased, while at the late course, tqixueliangkui and ganshenyinxu were more common.The relationship between syndrome type of traditional Chinese medicine and Western medicine clinical type, liver type showed mainly the shireneiyun syndrome, cerebral showed mainly the tanshizuluo, brain visceral showed mainly the ganfengneidong, ganshenyinxu, shireneiyun. The relationship between TCM syndrome type and disease severity, type Ⅰ were mainly found in ganshenbuzu, type Ⅱ were mainly found in shireneiyun, type Ⅲ were mainly found in ganfengneidong, qixueliangxu, type Ⅳwere mainly found in ganshenyinxu. The ganshenyinxu and qixueliangxu penetrated through the entire disease process. While the proportion of shireneiyun, tanshizuluo, qizhixueyu, tanmengxinqiao and tanyuhujie domenstrated a gradually increasing trend with disease progression.