Analysis On The Relation Between Metabolic Syndrome And Its Components And Urinary Stone

Objective:To analyze the relationship between MetS and its components and urinary stone.Methods:we designed a single-center case-control study in Minimally Invasive Urology Center,. The case group includes253urinary calculi patients who admitted to our center during the period from July2011to December2013. These patients are confirmed urinary stone by B-ultrasound, abdominal plain film, CT and other tests. Extracorporeal shock wave lithotripsy, percutaneous nephrolithotomy, ureteroscopy lithotripsy are used to treat uriary stones. Stones are measured with infrared stone components analysis system. The controls admitted to the same hospital. All of them are confirmed to be non-stone inpatients with no history of urinary stone through questionnaires and accepting at least once B-ultrasound during their stay in hospital. We have adopted a strict match of age and gender between patients in two groups to minimize the selected bias. Then, quantitative analysis of the correlation between MetS and its components and the overall incidence of urinary stone and incidence of different stone components was carried out and a meta-analysis up to December2013was conducted to derive the overall OR value of MetS on the risk of urinary stone formation. In this study, MetS was defined as the set for the CDS standards of the population, that at least three of the following conditions:diabetes, hypertension, obesity. high triglyceride/high low density lipoprotein. Results:The case-control study by the non-conditional Logistic regression analysis showed that OR of each risk factor on the total incidence of urinary calculi were as follows:diabetes,1.65(95%CI,1.43-1.91); hypertension,1.27(95%CI,1.08-1.70); obesity,1.33(95%CI,1.06-1.59); dyslipidemia,1.16(95%CI,1.10-1.21), MetS,1.73(95%CI1.42-2.83).The OR values of MetS on calcium stones or uric acid stones were:1.42(1.22-1.68),4.48(2.87-5.80).The meta-analysis(including5cross-sectional study and our control study) found the total OR of MetS on urinary stone is1.34(95%CI,1.14-1.56)Conclusion:1. MetS and its components are correlated with the incidence of urinary calculi and diabetes is the most important risk factor.2. MetS has differences in correlation with different components of urinary calculi. It correlated with uric acid stones more closely than calcium stones. It is also significantly correlated with calcium stones, but the strength of the association is weaker.