A Case-control Study Of Factor Analysis And Risk Factors Of Metabolic Syndrome

Objective:To explore the accumulation characteristics of the components of metabolic syndrome (MS) and to know risk factors for MS in health population based on people taken general health examination.Methods:With case-control study,130 cases and 130 controls from people who took medical examinations in Tianjin First Central Hospital and first diagnosed with MS in Tianjin Chest Hospital from July to November in 2010 were randomly selected. Using self-designed questionnaire, laboratory testing and physical examination, all subjects in both case and control group were taken investigated. Factor analysis and unconditional logistic regression were used for the components and risk factors of MS.Results:1. Three main factors for MS were identified in subjects by factor analysis: Factor 1 (including WC, WHR, BMI, TG and HDL-C), Factor 2 (including WC, SBP, DBP and FBG) and Factor 3 (including LDL-C). Factor 1 and Factor 2 connected each other with the effect of WC.2. Results from univariate logistic regression analysis showed that risk factors of MS included:smoking (OR=1.434,95%CI: 1.106～1.860), salty diet (OR=2.887,95%CI:1.719～4.847), oil consumption per capita monthly (OR=4.000,95%CI:2.002～7.922), fat meat diet (OR=2.050,95%CI: 1.239～3.392), daily intake of poultry meat (OR=1.455,95%CI:1.000～2.116), daily intake of lifestock organs (OR=2.182,95%CI:1.209～3.939), toasted or pickled food (OR=1.548,95%CI:1.139～2.104), dinner satiety(OR=4.390,95%CI:2.000～9.233), night snack (OR=6369,95%CI:1.818～22.177), school-age obesity(OR=2.190, 95%CI:1.419～3.379), central obesity (OR=11.035,95%CI:6.019～20.230), family history of hypertension(OR=3.351,95%CI:1.867～6.104); and protective factors for MS included:education level (OR=0.340,95%CI:0.235～0.492), income per capita monthly (OR=0.716,95%CI:0.550～0.932), housework(OR=0.439,95%CI: 0.266～0.724), physical exercise (OR=0.335,95%CI:0.233～0.481), daily fruit intake (OR=0.524,95%CI:0.374～0.735), daily intake of milk and its products(OR=0.497, 95%CI:0.355～0.695).3. Multivariate logistic regression analysis showed that risk factors for MS inluded:oil consumption per capita monthly(OR=3.679,95%CI: 1.330～10.182), dinner satiety (OR=6.816,95%CI:2.055～22.612), family history of hypertension (OR=3.525,95%CI:1.532～8.111), central obesity(OR=14.267,95%CI: 6.095～33.398); and protective factors of MS inluded:education level(OR=0.360, 95%CI:0.218～0.592), housework (OR=0.315,95%CI:0.179～0.783), physical exercise (OR=0.432,95%CI:0.263～0.708), daily fruit intake(OR=0.511,95%CI: 0.311～0.839).Conclusion:The fouding of three main factors by factor analysis prompted that the patholodical mechanism of MS occurrence may have more than one path and obesity played a major role in the aggregation of metabolic abnormalities. The occurrence of MS is influenced by multiple factors. The health recommendation for people with MS or with related risk factors is suggested, it should be acting by quiting smoking, reasonable distribution of meals, appropriate reducing intakes total fat, cholesterol and saturated fatty acid in daily food, increasing dietary fiber intake, engaging in regular and moderate physical exercise. The people who have family history of MS or its components should be supervised as key monitoring population with high-risk for MS, and primary prevention measures would be taken to prevent the occurrence of MS.