Study Of The Changes Of IL-18,IL-18BPa,IL-37and Their Relationships With Cardiac Function In Patients With Chronic Heart Failure

Objective：In recent years, a large number of studies have shown thatimmune inflammatory activation plays an important role in Chronic Heartfailure(CHF). IL-37is a new anti-inflammatory cytokine, and it can combinewith IL-18BP and enhance IL-18BP inhibition of IL-18. So far, the relationshipbetween IL-37and CHF has not yet been reported. We aim to investigat theassociation between plasma IL-18,IL-18BPa, IL-37levels and chronic heartfailure in this study.Methods: Fifty-seven CHF patients were divided into three subgroupsaccording to the New York Heart Association (NYHA) classification system：CHF1group (NYHA class II,8cases), CHF2group (NYHA class III,29cases)and CHF3group (NYHA class IV,20cases), of which18patients werediagnosed as ischemic heart disease (group IHD),39were non-ischemic heartdisease(group NIHD).Thirty healthy individuals were enrolled as control group.The plasma IL-18,IL-18BPa,IL-37levels were measured byEnzyme-linked Immunosorbent Assay (ELISA).Results：（1）The plasma levels of IL-18,IL-18BPa,IL-37were significantlyhigher in CHF group compared with control subjects（260.65±112.48VS116.39±39.06pg/ml、557.10±169.18VS384.16±80.07pg/ml、0.118±0.104VS0.049±0.036ng/ml, respectively, P<0.05）；（2）There were not significantdifferences of the plasma levels of IL-18, IL-18BPa,IL-37between IHDgroup and NIHD group （252.32±114.18VS264.50±112.97pg/ml、569.19±133.38VS551.52±184.72pg/ml、0.142±0.114VS0.108±0.099ng/ml,respectively,P>0.05）；(3) A correlation analysis showed that the plasmalevels of IL-18, IL-18BPa, IL-37were positively correlated with eachother(r=0.714、0.572、0.455，respectively,P<0.01);(4) The plasma levels ofIL-18,IL-18BPa, and IL-37were strongly negatively correlated with LVEF inCHF patient（sr=-0.501、-0.367、-0.430,respectively, P<0.01），and was positivelycorrelated with NYHA classification of CHF patients (r=0.411、0.500、0.370，respectively, P<0.01).Conclusion: There are significant correlations between the plasma levelsof IL-18,IL-18BPa, and IL-37and the severity of CHF．However，there are nosignificant correlations between the plasma levels of IL-18,IL-18BPa, and IL-37and the basis of chronic heart failure causes.