The Influence Of Metabolic Syndrome And Its Components On The Development Of Benign Prostatic Hyperplasia

Objectives: We aim at investigating whether there is a significantassociation between the development of benign prostatic hyperplasia andmetabolic syndrome(MS) along with its components.Methods: With a definite diagnose of benign prostatic hyperplasia(BPH) during routine checkup in the Health Examination Center of ourhospital,88middle-aged males were enrolled in our cohort duringMar,2012to Jul,2012. Middle-age is defined as45-59years, according tothe new age cohort standard of World Health Organization. Each patient’smedical history was delicately acquired together with their lower urinarytract syndrome (LUTS) based on the international prostate syndromescore (IPSS) and Quality of life score (QOL) questionnaire. To obtain ageneral information of overall patients, height, weight, Body mass index(BMI), blood pressure and prostate volume (PV) were collected.Metabolic data includes serum fasting blood glucose(FPG), totalcholesterol(TC), triglyceride(TG), low density lipoproteincholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C) and theProstate specific antigen(PSA). Diagnostic method for MS was strictlyobeyed to standard raised by CDS in2004. All subjects were divided into2groups, experimental group (36BPH complicated by MS) and control group (52pure BPH). The main objective was to compare theBPH-related index differences between BPH patients and patients withBPH complicated by MS. All patients were separated as follows, normalbody weight group, overweight group and obesity group based on bodymass index. For the purpose of comparing metabolic related datarespectively, patients were divided into another3paired groups accordingto TG, blood pressure and blood glucose. And intergroup BPH-relateddata were compared with statistical means. All collected data wereanalyzed via the Statistical Package for Social Sciences, version20.0(SPSS, Chicago, IL). Measurement date interclass was indicated withx±s. The count date was expressed by cases and percentage. Thecomparison between groups were tested using t test. The frequenciesbetween the cases and controls were tested usingχ2test.Results：1、Experimental group’s PV value is significantly higherthan that of control group(p=0.048).2、The overweight and obese BPH groups showed a higher levels of PVwith statistical significance, however PSA、IPSS and QOLS in thesegroups showed no obvious difference between each one another.3、The TG had no influence on BPH-related indexes.4、Patients’ IPSS in control group with elevated BP was significantlydifference compared with that in experimental group, however, PSA,PVand QOL in these two groups demonstrated no significant difference. 5、 PV collected from patients with elevated blood glucose wassignificantly different from patients with normal blood glucose（p=0.009,whereas, PSA,PV and QOL in these two groups demonstratedno significant difference.Conclusion:1、MS has markedly influence on the development ofBPH for middle-aged males.2、Overweight、obesity、elevated PBS andelevated BP have markedly influence on the development of BPH formiddle-aged males.3、TG has no influence on the development of BPHfor middle-aged males.