| ObjectivesThe purpose of this study was to evaluate the relationship between benign prostate hyperplasia(BPH) and metabolic syndrome(MS)in Geriatrics Department. To analyze the metabolic indexes including waist, body mass index(BMI), lipids, free blood glocuse(FBS), insuline resistance(IR) which affect BPH, so as to explore the effect of MS on the occurrence and development of BPH.MethodsIn the cross-sectional study,101 elderly BPH patients(aged≥60y) were recruited from Geriatrics Outpatients, Second XiangYa hospital in Feb,2008 and People's Liberation Army 163 hospital in March,2009. The metabolic indexes such as BMI, waist, lipids, FBS, free insuline(FINS)and BPH related datas containing prostate volume(PV), prostate specific antigen (PSA), international prostate symptom score(IPSS), course of BPH were collected and recorded, then were calculated statistically. All BPH patients were divided into two groups(the BPH with MS group and the BPH group) according whether they were diagnosed BPH and MS.The study was to compare the differences in indexes of prostatic hyperplasia in BPH with MS group and the BPH group.In addition, all patients were divided into differents groups according to level of BMI, waist, high density lipoprotein cholesterol (HDL-C),FBS,homeostasis model assessment of insuline resistance index (HOMA-IR) and assessed respectively the effect of these metabolic indexes on BPH. All descriptive data were reported as the mean±standard deviation(M±SD).The differences in the mean values between two groups were analyzed by Independent Samples T test, ANOVA, and LSD-test were used for multiple comparison. Enumeration data were reported as percentage, the analysis of correlation were used Pearson correlation and multiple liner regression.Significance was defined at the 5% level. Results1.The BPH with MS group showed significantly higher values of PV(51.19±25.64ml vs 38.34±13.67ml, P=0.003)and longer course of BPH(14.46±6.32y vs 11.51±6.32y, P=0.046) than in pure BPH group.2.The overweight and the obese BPH patients had significantly higher levels of PV(49.44±26.83ml,51.66±22.23ml) (P=0.021, P=0.043) than BPH patients with normal weight (38.10±10.64ml), the differences in PSA, course of BPH, IPSS between two groups weren't statistically significant(P>0.05).Additionally, BPH patients with BMI≥24kg/m2 combined abdominal obesity group had significantly higher levels of PV(50.26±26.51ml vs 38.99±11.25ml, P=0.005)than BPH patients without abdominal obesity, the differences in PSA, history of BPH, IPSS between two groups weren't statistically significant(P>0.05).3.BPH patients combined low levels of high density lipoprotein had significantly higher prostate volume than normal levels of high density lipoprotein BPH patients(54.23±28.92 vs 40.40±14.87ml, P=0.009), the differences in PSA, course of BPH, IPSS between two groups weren't statistically significant(P>0.05).4.The values of PV(50.40±22.56 vs 41.16±20.80ml,P=0.035), PSA(3.29±2.44 vs 1.91±1.47ng/ml, P=0.013)in the BPH patients with elevated FBS were significantly higher than the BPH patients with normal value FBS.5.BPH patients combined with IR (HOMA-IR>2.8) had higher values of PV than the insuline sensitive BPH patients(56.40±27.32 vs 39.41±15.67ml, P=0.001), the former group had longer courses of BPH than the latter group(16.61±7.73 vs 11.23±7.15y, P=0.001),the differences in PSA, IPSS weren't significant.6.The values of PV of all patients were positively correlated with BMI(r=0.459, P=0.000), FINS(r=0.421, P=0.001), HOMA-IR(r=0.490, P=0.003)and negatively correlated with HDL-C(r=-0.378, P=0.000), and they had no significant correlation with waist, FBS,2-hour postprandial blood glucose(2hPBG), low density lipoprotein cholesterol(LDL-C),HbA1C,totalcholesterol(TC), triglyceride(TG). Multiple linear stepwise regression analysis showed that prostate volume was most closely correlated with HOMA-IR.Conclusions1.BPH patients combined with obesity, abdominal obesity, low levels of HDL-C, elevated FBS,IR had the larger values of prostate volume, BPH patients combined with IR had longer course of BPH.2.Level of BMI, FINS,HOMA-IR were positively correlated with PV, and HDL-C was negatively correlated with PV.In numerous metabolic indexes, HOMA-IR was correlated with PV most closely.3.MS had evident effect on the occurrence and development of BPH. |
