The Analysis Of Correlation Between Gonadotrophin Surge Attenuating Factor (GnSAF) Of Serum And PCOS

Objective: Through detection the density of gonadotrophin surgeattenuating factor (GnSAF) in serum，to analyze the correlation betweenGnSAF and PCOS and its clinical application.Methods: Totally76patients with PCOS，67healthy females and7thatovarian features recession were enrolled from October2011to June2012inthe First Hospital of Jilin University. Serum GnSAF levels were measuredby enzyme linked immunosorbent assay（ELISA）. Gonadal hormone、OGTT and Ins levels were measured and the follicle numbers were recordedby transvaginal Doppler ultrasonograph.Result:(1) all of the research object of150cases，including76cases ofPCOS group，67cases in the control group and7that ovarian featuresrecession. PCOS compared with the control group of age and WHR，nosignificant difference. BMI was statistically significant differencebetween two groups.(2) in PCOS group compared with the control group，GnSAFlevels were22.11±6.71pg/ml and20.11±5.92pg/ml，PCOS groupwas higher than control group,but the difference was not statisticallysignificant (P=0.062).(3) except for FSH and E2，the PCOS group and the controlgroup，LH，T levels and LH/FSH were significantly higher than that of control group (P <0.01， P <0.01， P <0.01)， there was statisticallysignificant difference between two groups.(4) PCOS group GnSAF was negatively correlated trend withFSH and E2，while positively with LH and T，normal group GnSAFand was negatively correlated with the hormone， but had no statisticalsignificance.(5) GnSAF concentration was positively correlated trend with thenumber of follicles and negatively correlation trend with FSH， thedifference had statistical significance.Conclusion:(1) GnSAF level have no correlation with the pathogenesis ofPCOS and follicular disorder，further study requires large samples;(2) be meaningful to predict ovarian reserve function.