| The Chinese medicalization of western medicine has been proposed more than30years, some achievements have obtained through clinical experience accumulation. However, the progress is quite slow, since there is absence the simple and scientific experimental method. Our laboratory has already established the cytological methods to evaluate cold and hot characteristics of traditional Chinese medicines, and has extended this method to the researches of Chinese medicalization of western medicine. This thesis will continue this research and evaluate cold and hot characteristics of three kinds of western medicines, i.e., the antibacterial drugs, antiulcer drugs and anti-arrhythmic drugs. The results show2of18evaluated antibacterial drugs are hot, others are cold; in9antiulcer drugs, aluminum hydroxide, sodium bicarbonate, cimetidine, omeprazole and pantorazole are cold and ranitidine, famotidine, lansoprazole and rabeprazole are hot; in7anti-arrhythmic drugs, diltiazem, verapamil, amiodarone and propafenone are cold and metoprolol, bisoprolol and carvedilol are hot. At the same time, more than30simple compounds are evaluated in order to reveal structure activity relationship. The results showed that the compounds with the benzene rings are cold and hydroxyl substitutions are hot.Cold and hot characteristics of Chinese traditional medicines can affect the body’s energy metabolism, it is speculated that they may also affect cell energy metabolism. Therefore, two key substances NADH and ATP in the cell energy metabolism are chose as the objects to determine the effects of traditional Chinese medicines on them. The results showed that traditional Chinese medicines with the hot characteristic could intensify the fluorescence of NADH and the traditional Chinese medicines with the cold characteristic are almost no effect on NADH. This is the first study of the effect of traditional Chinese medicines on NADH and ATP in the cells, offering a new way for the research of traditional Chinese medicines. |
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