The Study On The Pharmacy And Pharmacodynamics Of Majiang Xuanfei Capsule

Objective: On relieving cough and asthma Majiang Xuanfei capsule and its preparation technology and quality standard were studied, and the preliminary investigation on the stability of cough and asthma. And by studying the Majiang Xuanfei capsule indices such as cough, asthma, expectorant the pharmacodynamics research. Study the effect of Majiang Xuanfei capsule and the safety of the drug.Methods:On relieving cough and asthma Majiang Xuanfei capsule preparation process stability and pilot study. Is studied through experiments and the appearance of the Majiang Xuanfei capsule properties, moisture content, heavy metals and arsenic salt content, the difference of filling quantity and hygiene, and the purple Perilla leaf, phlegm, coltsfoot flower microscopic identification, and TLC method for the flax Jiang Xuan lung capsule of ephedra ingredients identification of pinellia, radix paeoniae alba, method, establish the drug quality standard. With accelerated test method in the stability test and room temperature sample survey. Of Majiang Xuanfei capsule respectively with ammonia method, phenol red, mice ear swelling, acetylcholine and histamine phosphate breath method, capillary method in vitro the trachea, endotoxin and bacteriostatic ring method to carry on the antitussive, expectorant, smooth wheezing, anti-inflammatory, antipyretic, and bacteriostatic research. Maximum dosage of Majiang Xuanfei capsule dose experiment, rats lavage for7days, each day to see the diet and activity of mice, with and without death. And with and without pathological changes anatomical observation in mice organs.Results:Majiang Xuanfei capsule preparation:the purple Perilla leaf, phlegm, coltsfoot flower three ingredients crushed into fine powder,80mesh sieve; Other ephedra, cassia twig, pinellia eight herbs, such as boiling water for2times,2hours for the first time, another1.5hours, and filtration, respectively, to merge two extract, enriched to clear cream of relative density is1.15-1.25(80℃), then the decompression drying, and then crushed into fine powder, merged with the fine powder, sieving, mixing, granulating, capsule, packaging, Co60irradiation sterilization. Majiang Xuanfei capsule quality standard:for hard capsule, contents is red brown powder; Sheen and slightly bitter taste, and its effective composition content conform to the standard. Majiang Xuanfei capsule content not more than300bacteria per gram, the mould and yeast content not more than100per gram, did not check out, staphylococcus aureus, escherichia coli, live with and verdigris, pseudomonas bacteria. Experiments show that the stability of the Majiang Xuanfei capsule drug appearance character, inspection, identification, hygiene inspection without obvious changes in the indicators such as six months. Hemp Jiang Xuan pharmacodynamics experiment of lung capsule: can effectively reduce and the frequency of cough in mice, can increase the amount of phenol red drain respiratory tract in mice, also can reduce caused by endotoxin in rats increased body temperature, and can extend the guinea pigs induced cough incubation period, also can mouse ear swelling caused by dimethylbenzene have inhibition, as well as to the staphylococcus aureus, beta hemolytic streptococcus, diplococcus lanceolatus have certain bacteriostatic effect. Majiang Xuanfei capsule in mice maximum dosage is37.54g/kg, equivalent to729.9times that of the adult dosage in clinic, observe mice activities during normal, eating, drinking, and the colour is normal, no abnormal phenomenon. Therefore believe that the drug clinical oral medication safety.Conclusion:By Majiang Xuanfei capsule pilot study shows that the drug preparation process stability is good, the quality inspection in accordance with national standards. The stability test results show that completely accords with the quality standard of preclinical medicine of the show that Majiang Xuanfei capsule quality basic stability during storage, the storage life is temporarily set at24months. Majiang Xuanfei capsule can effectively to a cold cause cough, much sputum, fever, inflammation, etc. With good inhibitory effect. Acute toxicity experiment, the experimental animals without abnormal behavior, and dosage is much higher than that of clinical dosage, Majiang Xuanfei capsules clinical medication safety.