The Study On The Pharmacy And Pharmacodynamics Of Zhike Pinchuan Capsule

Objective:1, on relieving cough and asthma capsule and its preparation technology and quality standard were studied, and the preliminary investigation on the stability of cough and asthma.2, antitussive and expectorant experiment index for relieving cough and asthma capsule pharmacodynamics research. Discussion on the therapeutic effect of Zhike Pingchuan capsule and drug safety.Methods:1, on relieving cough and asthma capsule preparation process stability and pilot study. Investigate its moisture content, heavy metals, arsenic salt content, disintegration time, load difference and hygiene, on phellodendron, licorice, ephedra, gypsum, Pericarpium Citri Reticulatae were microscopic identification, while the use of thin layer chromatography on Qingfei Huatan granule of ephedra, treats for component identification, to establish the quality standard of drugs. The stability study of accelerated test method at room temperature and sample observation method.2, respectively, using aqueous ammonia, phenol red, endotoxin, mouse ear swelling and bacteriostatic ring on antitussive, antiasthmatic Zhike Pingchuan capsule, expectorant, antipyretic, anti-inflammatory, antibacterial action by the line of research. In3, the maximum dosage on murine intragastric administration for7days, the observation of the mouse diet and activity, with no death appeared. Anatomical observation of mouse organs have no pathological changesResults:1, relieving cough and asthma capsule preparing process for: ephedra, tangerine peel, Fritillaria ussuriensis, bitter almond ten ingredients are ground into fine powder, over80mesh sieve, adding proper amount of starch and the fine powder and evenly mixed,85%ethanol granulation,40mesh sieve granule, capsule, packaging, Co60irradiation sterilization.2, quality standards:the product is capsule, the contents is brownish yellow powder; gas smell, taste bitter, effective ingredients content standards. Mould content per gram of not more than100, yeast content per gram of not more than100, coliform content per gram of not more than10, were not detected in Escherichia coli, living, Salmonella, Staphylococcus, Pseudomonas, Pseudomonas bacteria.3, the experimental results show that the drug stability, appearance character identification, inspection, hygiene and other indicators within three months were not significantly changed.4, pharmacodynamic experiment shows, Zhike Pingchuan capsule can effectively reduce the experimental animal cough frequency and number of times, increased respiratory phenol red excretion, decreased by endotoxin caused by elevated body temperature, prolong the latent period of cough guinea pigs, inhibit ear swelling of mice induced by xylene in two, against Staphylococcus aureus, Streptococcus pneumoniae, hemolytic streptococcus pyogenes has certain antibacterial effect.5, cough and asthma relieving capsule of the mouse stomach lavaging of maximum dose of29.25g/kg, equivalent to379.14times the amount of clinical adult, and dosing during murine normal activities, the water eating normal color luster, no abnormal phenomenon. So that, the medicine clinical oral medication safety.Conclusion:1, relieving cough and asthma capsule pilot study showed the drug preparation, good stability, quality inspection in full compliance with national standards. Cough and asthma relieving capsule stability test results consistent with preclinical drug quality standard requirements, the preparation in the quality of basic stability during storage, storage period is tentatively scheduled for24months. In2, relieving cough and asthma capsule can effectively to cold caused by coughing, sputum, fever, inflammation, and has good inhibition. In3, acute toxicity test, experimental animal abnormal behavior, and the dosage is much higher than that of clinical dosage, Zhike Pingchuan capsule clinical medication safety.