Enhance-flow And Spectral Doppler Study The Hemodynamics Of Ophthalmic Artery In Hyperuricemia

Objective: To study the inner diameter and hemodynamics ofophthalmic artery(OA) and central retinal artery(CRA) in hyperuricemia byEnhance-flow (eFlow) imaging and spectral Doppler. And explore therelationship of the uric acid and the hemodynamics of ophthalmic inhyperuricemia. And to learn the relationship between high uric acid hematicdisease and peripheral vascular disease.Methods: One hundred and one patients with hyperuricemia, twentyprimary hypertension patients and thirty healthy volunteers were selected, theinner diameter in eFlow imaging and the peak systolic velocities(PSV), theend diastolic velocities(EDV), the resistive index(RI), pulsatility index（PI）of OA and CRA by spectral Doppler imaging. The101patients weredivided into two groups according to the time of diagnosing hyperuricemia,one group had a diagnosis of hyperuricemia for more than five years and theother had such a diagnosis for less than five years. The data were comparedby t-test. Then, the patients were further divided into a group ofhyperuricemia combined with hypertension and the other withouthypertension. The differences between the experimental groups and the groupof volunteers were were carried out by One-way ANOVA, the comparisonbetween two groups were analyzed with SNK. The data of the group ofprimary hypertension and the group of hyperuricemia with hypertension werecompared by t-test. We conducted a Pearson association analysis between theUA levels of the group of hyperuricemia and hemodynamic index. Results:(1) The RI(0.68±0.09) and PI(1.3±0.4) of OA in patients whowere diagnosed as hyperuricemia for more than5yaers washigher[RI:0.63±0.09, PI:1.1±0.3(t=3.504, P=0.001；t=3.164, P=0.002),theEDV[(6.4±3.4)cm/s] of OA was lower than those patients with a diagnosisof hyperuricemia for less than5years [(7.5±4.8)cm/s, t=1.988, P=0.049];(2)The PSV[(11.5±3.5)cm/s] and EDV[(3.7±1.1)cm/s] of CRA inhyperuricemia combination hypertension group was lower, and theRI(0.88±1.40) was higher than hyperuricemia without hypertensiongroup[PSV(13.5±4.0)cm/s, EDV(4.1±1.2)cm/s, RI:0.67±0.08].(3) The RI, PIof the OA in hyperuricemia with hypertension group(RI:0.73±0.68、PI:1.62±0.37) was higher than the group of the primary hypertension（0.67±0.73、1.48±0.27）.(4) RI of group of ophthalmic artery and CRAinnerdiameter and the normal group no significant statistical difference (P>0.05).(5) Among the hyperuricemia subjects with normal blood pressure, Pearsonassociation analysis showed significant associations between the UA and RIof the OA (r=0.274,P=0.007) and the UA and PI of the OA (r=0.318,P=0.001).Conclusion: By eFlow and spectral Doppler, we have found thathyperuricemia could accelerate OA and CRA atherosclerosis. The eFlow andspectral Doppler are valuable methods to study the hemodynamics inophthalmic artery of patients with hyperuricemia.