The Value Of Ophthalmic Artery Blood Flow Velocity Fluctuation In Predicting Intracranial Hypertension

Objective To assess the diagnostic reliability of ophthalmic artery blood flow end diastolic velocity changes( △ V) monitored by transcranial doppler(TCD) in predicting intracranial hypertension in patients with brain injury.Methods The patients who underwent craniocerebral operation and continuous invasive intracranial pressure(ICP) monitoring during March to November in 2014 were recruited. The blood flow parameters in different segements of ophthalmic artery were measured with TCD, and the △Vs were calculated. Receiver operating characteristic(ROC) analysis was used to evaluate the flow velocity change of ophthalmic artery in predicting intracranial hypertension.Results The biggest area under ROC curve(AUC) was obtained while the rate flow velocity change of ipsilateral ophthalmic artery [△V(60-48)/48] was applied for predicting intracranial hypertension(ICP>20 mm Hg). The diagnosic sensitivity, specificity and AUC were calculated using a cutoff point of 0.12, and found to be 76.5%, 75% and 0.717.Conclusion The ophthalmic artery blood flow end diastolic velocity changes is an acceptable noninvasive indicator of intracranial hypertension in patients with brain injury, its diagnostic value need further investigation.