Expression And Clinical Significance Of Chemokine Ligand7in Oral Leukoplakia And Oral Squamous Cell Carcinoma

Oral leukoplakia is included in precancerous lesions by WHO.Oral squamous cell carcinoma is the most common tumor of oral andmaxillofacial malignant tumor,which is strong local invasion of squamouscell carcinoma、often to the regional lymph node metastasis and distantmetastasis-prone late. Currently its main effective treatment is stillsurgical excision, even if adjuvant radiation therapy, chemotherapy andother comprehensive sequence treatment, and its prognosis is often poorsurvival rate. Therefore, in order to prevent early oral squamous cellcarcinoma, discovery and diagnostics, improving the quality of life andsurvival of patients with oral squamous cell carcinoma, the developmentof mechanisms for oral squamous cell carcinoma being deep studied andtaking targeted individualized comprehensive sequence treatment are veryimportant.A large number of studies have shown that a variety of immunefactors, chemokines and their receptors play an important role in thedevelopment of tumors. CCL7is a member of the CC chemokine family,which plays an important role in the recruitment of monocytes, tumormetastasis and other biological effections.Studies have shown that thisfactor is related to tumor’s development and metastasis in cervical cancer,pancreatic cancer, gastric cancer, colorectal cancer and other malignanttumor. CCL7expression is with less the case studies in oral squamouscell carcinoma, and the study using immunohistochemical techniques,preliminarily studying the expressio of CCL7in noral leukoplakia andoral squamous cell carcinoma,associating with clinical data,analyzedthe expression of CCL7among them. ObjectiveTo detect the expression of CCL7in oral leukoplakia and oralsquamous cell carcinoma tissue, analyze the clinicopathologicalparameters of oral squamous cell carcinoma and explore the role of CCL7occurred in precancerous maligant and oral squamous cell carcinoma’sdevelopment.Materials and Methods1Sample Data:18cases of oral leukoplakia organizations, including12cases of simple hyperplastic leukoplakia, six cases of moderate tosevere proliferative leukoplakia;35cases of oral squamous cell tumors,including12cases of well-differentiated squamous cell carcinoma,13cases of moderate or poor differentiated squamous cell carcinoma, and10cases of moderate or poor differentiated and associated with cervicallymph node metastatic squamous cell carcinoma;11cases of normal oralmucosa;2Experimental Methods: CCL7were detercted byImmunohistochemical method(SABC);3Statistical Methods: The resulting experimental data were analyzedby using the SPSS19.0software analysis, statistical analysis between thegroups positive rate of immunohistochemical and clinical pathologygrading count data were compared by using the X2test, the mean opticaldensity values was analyzed by using the t test,and p <0.05wasconsidered statistically significant.ResultThe expression of CCL7in oral squamous cell carcinoma tissue washigher than that in oral leukoplakia and normal oral mucosa, and thedifference was statistically significant (p <0.05). The expression of CCL7in oral squamous cell carcinoma of the late stages of clinical tissue with lymph node metastasis was higher than that in early clinical withoutlymph node metastasis tissue, p <0.05, a statistically significantdifference. The expression of CCL7in white tissue hyperplasia withmoderate or severe hyperplasia was higher than that in white tissuehyperplasia and normal oral mucosa, p <0.05, a statistically significantdifference.ConclusionThe higher expression of CCL7in severe dysplasia of leukoplakiaand oral squamous cell carcinoma tissue, and related to the clinical stageand lymph node metastasis, suggested that CCL7may possibly play arole in the development of malignant transformation of oral premalignantlesions and oral squamous cell carcinoma.