| Objective:Through the investigation in the crowd of CAG with anxiety and depression of TCM syndrome type and detecting GAS, MTL, it is obtained of the distribution of TCM syndrome characteristics of CAG with anxiety and depression, and the relationship with GAS, MTL. Further explore the emotional factors influence on TCM syndrome type and GAS, MTL in the pathogenesis of CAG. It can provide reference for the study of the crowd of CAG with anxiety and depression by combining Traditional Chinese and Western Medicine treatment.Methods:Collect89patients with CAG of meeting the conditions through evaluation of HAD. HAD score>8points in60cases, HAD score<8points in29cases. The subjects were conducted for TCM syndrome differentiation according to standard of TCM syndrome types. The stomach mucosa was taken in the fasting for gastroscopy. Samples were collected and conducted for RNA extraction, RT reaction, PCR reaction and calculating expression of mRNA. By the statistical method, compare TCM Syndrome type and GAS, MTL between the crowd of anxiety and depression and non anxiety and depression, and compare the TCM syndrome type and GAS, MTL.Result:The difference was statistically significant compared with the crowd of anxiety and depression and non anxiety and depression of TCM syndrome type (P<0.05). In the crowd of anxiety and depression, the disharmony between liver and stomach syndrome was the main syndrome, or concurrently with the damp heat in spleen and stomach, weakness of the spleen and stomach. In the crowd of non anxiety and depression, the damp heat in spleen and stomach, weakness of the spleen and stomach syndrome were the main syndrome. The infection rate of Hp, the degree of atrophy and intestinal metaplasia had no significant difference in the crowd of anxiety and depression and non anxiety and depression(P>0.05). GAS mRNA expression of anxiety and depression group is lower than the non anxiety group (P<0.05). MTL mRNA expression of anxiety and depression group is lower than the non anxiety group (P<0.05). Compare main TCM syndromes with GAS, MTL mRNA expression in anxiety and depression group and non anxiety and depression group:In anxiety and depression group, GAS mRNA expression of disharmony between the liver and stomachH-damp heat in spleen and stomach, disharmony between the liver and stomach+weakness of the spleen and stomach syndrome were lower than that of disharmony between liver and stomach syndrome (P<0.05). There is no statistical significance of three main syndromes of difference in MTL (P>0.05). In non anxiety depression group, GAS, MTL mRNA expression of damp heat in spleen and stomach syndrome were higher than that of weakness of the spleen and stomach (P<0.05).Conclusions:Anxiety and depression was certain effects on TCM Syndrome type of CAG. The gastrointestinal hormone (GAS, MTL) in the crowd of anxiety and depression changes more significant than non-anxiety and depression. There is some connection in TCM syndrome and gastrointestinal hormone of anxiety and depression and non-anxiety and depression. The levels of GAS, MTL in part reflect the differences between TCM syndrome type of CAG. Whether the levels of GAS, MTL as CAG Syndromes secondary objective indicators, it needs further research, In the diagnosis and treatment of the CAG, in addition to considering combining the pathogeny and disorder, still need to consider the influence of emotional factors on disease of TCM syndrome type and development. Pay attention to social and psychological factors of disease. There is validity and necessity in a variety of psychological intervention for stomach disease. |
