The Clinical Observation Of Gengniananshen Decoction In The Treatment Of Patients With Hyperactivity Of Fire And Yin Deficiency Type Insomnia

Objective:1.Compare GengNianAnShen Decoction Combined with alprazolam group with alprazolam group to treat patients with hyperactivity of fire and yin deficiency type insomnia, in the change of before and after subjective symptoms and insomnia assessment scale scores, effection on serum5-Hydroxy tryptamine (5-HT),norepinephrine (NE),to investigate the clinical significance of GengNianAnShen Decoction.2.Summarize the clinical experience of my tutor, and provides a new idea for hyperactivity of fire and yin deficiency type insomnia treatment, improve the clinical efficacy.Methods:According to the standards of TCM syndrome diagnosis and treatment published by State Administration of traditional Chinese Medicine in the January1,1995and the third edition of china classification and diagnostic criteria of mental disorders diagnostic criteria (CCMD-3) formulated in2001.Select72cases of insomnia patients met the inclusion criteria,which reference medical statistics table,divided into treatment group and control group, each include36cases, continuous treatment for4weeks, and recorded before and after treatment in the Pittsburgh sleep quality index (PSQI), changes of subjective symptoms,5-HT,NE level in serum, observe the change of two group index.Collect fasting blood samples5ml which include at the beginning and after4weeks of treatment between6:30-8:00am, Using high performance liquid chromatography electrochemical method (HPLC-ECD) to measure levels of5-HT, NE in serum. Analysis of two group’s clinical efficacy and the effect on serum levels of5-HT, NE, discuss the relationship between the changes of serum levels of5-HT, NE and clinical symptoms.Results:1.Both groups could improve sleep, reduce PSQI integral of the patients, the difference was statistically significant, the treatment group was better than control group.2.Both groups could improve vexation and half asleep symptom of the patients, the treatment group was better than the control group. The control group had no statistical significance in feverish sensation over the palm and sole, tinnitus, hectic cheek, xerostomia, while the treatment group has obvious effect, and there is significant difference between the two groups. Both groups could not improve palpitations and forgetfulness symptom of the patients.3.The treatment group cured13cases, markedly effective11cases, effective8cases, invalid4cases, the control group cured7cases,markedly effective8cases,effective14cases, invalid7cases. The cure rate of the treatment group was36.11%, effective rate was88.89%; control group cure rate was19.44%, effective rate was80.56%.4.After treatment both groups could rise serotonin and reduce norepinephrine in the serum level, the treatment group was better than control group.Conclusion:1.Both groups were able to treat patients with hyperactivity of fire and yin deficiency type insomnia, improve subjective symptoms,GengNianAnShen Decoction had clinical efficacy in treating patients with hyperactivity of fire and yin deficiency type insomnia.2.Both groups could improve vexation and half asleep symptoms of the patients. GengNianAnShen Decoction had the clinical efficacy in treat patients with vexation,half asleep,feverish sensation over the palm and sole,tinnitus,hectic cheek,xerostomia symptoms.3.Both groups could rise serotonin and reduce norepinephrine in the serum level of the patients, GengNianAnShen Decoction could ameliorate serum levels of neurotransmitters.4.GengNianAnShen Decoction could treat patients with hyperactivity of fire and yin deficiency type insomnia, the mechanism may be related to ameliorate the level of serotonin and norepinephrine,the level of serotonin and norepinephrine in serum can be used for objective index for clinical studies of insomnia.