Cold And Heat Mixed Type Fullness Observed Efficacy Of Weikang Mixture

Objective:Randomized controlled using the experimental method,Weikang Mixture observed clinical efficacy of cold and heat mixed type fullness of patients, for cold and heat mixed type fullness provide clinical treatment programs in Fuzhou.Methods:1Screening from February2013to December2013, Fujian Province People’s Hospital for treatment of traditional Chinese medicine medical clinic and Doctors Court clinic a total of60patients were randomly divided into experimental group and control group of30patients, in the experimental group to of Weikang Mixtrue,14days for a course of treatment, the control group received conventional triple antibiotic therapy for14days, comparing symptoms before and after treatment, and signs and eradication rate of Hp of withdrawal a month.Assess Weikang Mixtrue mixed type of cold and heat treatment fullness clinical evaluation, and security testing.Weikang mixture consisting of: basil stems10g, Magnolia9g, Poria12g, ginger Pinellia10g, Scutellaria9g, berberine3g, ginger5g, North Hawthorn10g, Divine Comedy10g, licorice3g.These drugs for the Beijing Pharmaceutical Kangren appear to provide full ingredient formula granules, warm boiled water to200-300ml,1dose per day, morning and evening2times service,14days for a course of treatment.Control group using conventional triple antibiotic therapy:omeprazole enteric-coated tablets,20mg,2times every day (National Pharmaceutical Group Industry Co., approval number:Zhunzi H20094110)+amoxicillin capsules,1000mg,2times every day (Sichuan pharmaceutical Co., Ltd. Xiu, approval number: Zhunzi H51020246)+clarithromycin capsules,500mg,2times every day (Zhejiang Asia-Pacific pharmaceutical Co., Ltd., approval number:Zhunzi H20058223).13C-UBT Breath Test: urea [13C] capsules, atom-Tech Co., Ltd., approval number: State-word H20050572.During treatment, the patient is asked festival diet, careful living, proper cold temperature, Emotions and eat spicy food or too cold.2Fullness diagnostic criteria and syndrome diagnostic evidence:State Drug Administration experts to prepare the "guiding principles of Chinese medicine clinical research"; chronic superficial gastritis endoscopic diagnosis is based on:Refer to the country in2012, held in Shanghai "Chinese chronic gastritis consensus" the second form of chronic gastritis consensus conference; Hp infection diagnosis:13C-UBT breath test was positive.Results:1Comparison of individual symptom scores:Groups of epigastric pain, belching and acid reflux, mouth pain, dry mouth, stomach noisy, chest tightness, hi sigh, short yellow urine symptoms were significantly improved (P<0.01); Experimental group of epigastric or abdominal distention, loose stool, eating less, nausea and vomiting, there was a significant improvement (P<0.01), inactive control group (P>0.05); Better treatment of the experimental group than the control group tightness(P<0.05); Groups for fatigue, weakness, pale mouth are invalid (P>0.05).2Compare individual total symptom score:After the experimental treatment group individual symptoms and signs of (13.41±2.469) total score decreased to (5.78±1.528), treatment of individuals in the control group of symptoms and signs of (12.81±2.400) total score decreased to (7.58±1.629), achieved after treatment effect (P<0.05). After treatment, the experimental group than the control group integration, improve symptoms in the experimental group than the control group (P<0.05).3Comparison of The total effective: Experimental group after treatment effective in3cases (11.11%), effective24cases (88.89%), treatment group0cases (0%), effective in21cases (80.77%), the statistical comparison between the two groups was no difference in the total efficiency (P>0.05).4Hp eradication rate comparison:the experimental group Hp eradication rate was51.85%, in the control group Hp eradication rate was76.92%, the experimental group Hp eradication rate is higher than the control group. After statistical analysis, Hp eradication rate between the two groups was not statistically significant (P>0.05), comparable.5Safety Testing:According to observe safety testing, no obvious adverse reactions occurred during the experimental treatment group.Conclusion:1Weikang mixture improve symptoms better than the control group in treating cold and mixed type fullness.2Weikang Mixture can eradicate Hp certain extent(51.85%), compared to western triple therapy (76.92%) no advantage.3Weikang mixture is no significant adverse reactions in treating cold and mixed type fullness.In summary, Weikang mixture can reduce the clinical symptoms of cold and heat mixed type fullness of patients, clinical efficacy. Although can not completely kill Hp, but through its own state adjustment, symptoms improved significantly, and no significant adverse reactions, worthy of clinical use.