The Pharmaceutical Research Of Sanqi Shuluo Capsule

Sanqi shuluo capsule is a prescription undert the guidance of TCM theory, it combined with years of clinical practice to summarize, used in the treatment of angina pectoris of coronary heart disease. It is composed of Astragali radix, Notoginseng radix et rhizoma, Salviae miltiorrhizae radix et rhizoma. Chuanxiong rhizoma, Paenoiae radix rubra, a total of five herbs, with invigorating qi and promoting blood circulation, removing blood stasis and relieving pain, mainly used for the treatment of chest pain, chest tightness, palpitation spontaneous, fatigue, shortness of breath and so on caused by qi deficiency and blood. This issue is under the guidance of TCM theory, with the application of modern preparation technology, the drug was researched preparation techniques of formulations, set up the quality standards, and the stability test was carried out to research.In the study of the preparation process, according to the indication function of prescription and the physiconchemical property of each drug’s effective components, the single factor and orthogonal test used to optimization of the water extraction process of Astragali radix and Paenoiae radix rubra. Plus twelve times the amount of water, soaked two hours, extracted one hour, plus ten times the amount of water, extracted two times, each time one hour. The astragaloside. paeoniflorin and dry extract yield as the index; The optimum alcohol extraction process of Salviae miltiorrhizae radix et rhizoma and Chuanxiong rhizoma were determined by single factor test and orthogonal test, plus eleven times the amount of75%alcohol, extracted for1.5hours, plus ten times the amount of75%alcohol, extracted two times, each time1.5hours. The tanshinone Ⅱ A, salvianolic acid B, ferulic acid and dry extract yield as the index; The water extract and alcohol extract liquid was respective purified impurity, by vacuum concentration, purification liquid and concentrated liquid taken sponging drying, made into extract powder. The Notoginseng radix et rhizoma in the prescription into fine powder and mixed extract powder; By the single factor test. optimized the first-rank type and ratio of accessories, mixed drug powder andaccessories, used dry granulating. Selected0capsule, filled, namely. In the study of the quality standards, the TLC was used to identify Astragali radix, Notoginseng radix et rhizoma, Salviae miltiorrhizae radix et rhizoma, Chuanxiong rhizoma. Paenoiae radix rubra in the prescription. the chromatographic spots were clear, good repeatability, no negative interference; Used HPLC to determined the effective components of the monarch drug Astragali radix and Notoginseng radix et rhizoma, astragaloside, ginsenoside Rg1, ginsenoside Rb1and ginsenoside R1, and take methodology research. And tentatively the each capsule astragaloside content shall not be less than0.28mg, the total saponins content shall not be less than2.24mg.In the study of the stability test, adopt accelerating test and long term test investigated the stability of the Sanqi shuluo capsule, indicating that the preparations in clinical drug packaging, drug properties and stability in the one year.