| Objective:To investigate the expression of the lactoferrin mRNA and protein in human cervical cancer and analyze the relationship between lactoferrin and the stage,differentiation degree and lymphatic metastasis.Method:The expressions of lactoferrin in36biopsy tissue with pathologically confirmed cervical cancer and15normal cervical tissue were investigated by immunohistochemical and qRT-PCR technique. The correlation between lactoferrin and clinical stage, differentiation degree and lymphatic metastasis was analyzed.Result:Lactoferrin mainly located in cytoblast. The LF-positive cells in cervical cancer was significantly less than in normal cervical tissue by immunohistochemical (P<0.05). The low-expression of lactoferrin showed correlation with clinical stage and lymphatic metastasis, but no correlation with differentiation degree. The expression of lactoferrin mRNA in cervical cancer was significantly lower than in normal cervical tissue (P<0.05). There was correlation between low-lactoferrin mRNA with clinical stage and lymphatic metastasis.Conclusion:Lactoferrin was down expressed in cervical cancer at the levels of mRNA and protein. Lactoferrin is related to clinical stage and lymphatic metastasis. Lactoferrin likely played a role in genesis, development and metastasis of cervical cancer. |
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