| Objective:To detect the level of NSE in serum and resistance index of middlecerebral artery with ultrasonic of full-term asphyxia newborns,and explore the clinicalsignificance in early diagnosis of prediction of hypoxic ischemic encephalopathy ofNSE and RI in full-term asphyxia newborn, so as to provide theoretical basis for earlyintervention of HIE.Methods:Electrochemical luminescence method were used to detect69cases offull-term asphyxia neonates born after6hours,12hours,24hours of the serum levelsof NSE protein concentration, at the same time, application of transcranial dopplerultrasound to detect the middle cerebral artery resistance index, and3days after bornfull-term asphyxia newborns in the clear after the diagnosis of HIE, full-termasphyxia newborn again divided into suffocation HIE group and asphyxia of HIEgroup. Choose30cases of normal full-term newborn during this period, no history ofasphyxia and infection, and nervous system symptoms, electrochemical luminescencemethod were used to detect the6hours,12hours and24hours after birth the serumlevels of NSE protein concentration and the application of transcranial dopplerultrasound to detect the middle cerebral artery resistance index as the controlgroup.The obtained date uses the SPSS17.0to carry on the analysis.Results:①Asphyxia in serum levels of NSE protein of children with HIEgroup was obviously higher than that of asphyxia of children with HIE. And asphyxiaof HIE group serum NSE between protein content and normal control group hadsignificant difference (P <0.05). Comparison of asphyxia neonates born6h,12h,24h after the concentration of serum NSE protein, asphyxia, suffocation of HIE HIEgroup group and normal control group were peaked at6h after birth, followed by12h and24h.②Asphyxia HIE group of the middle cerebral artery resistance index valueof the suffocation of HIE children increased significantly, the difference was statistically significant (P <0.05).③using ROC curve analysis of serum NSE andmiddle cerebral artery resistance index of HIE diagnosis accuracy, and the serumNSE (12h after sampling) and RI value (born6h after cranial ultrasound monitoring)20.72ug/L,0.755to determine the sensitivity of the two groups and specific degrees.Results showed that12h after the birth of the sensitivity of the serum levels of NSEprotein prediction and specific degree is the highest,100%and70.6%, respectively.By cranial ultrasonography monitoring of middle cerebral artery resistance index topredict the sensitivity of the HIE and specific degrees6h after birth is highest,90.3%and95.6%, respectively. Such as testing at6h after birth middle cerebral arteryresistance index and12h concentration of serum NSE, can significantly increasesensitivity to HIE diagnosis prediction and specific degree,100%and95.6%,respectively, and reduce the false positive rate and false negative rate. Thus born jointmonitoring6h after12h after middle cerebral artery resistance index and serumlevels of NSE protein concentrations for diagnosis of best time and can significantlyincrease sensitivity and specific degree of HIE diagnosis prediction, and reduce thefalse positive rate and false negative rate, and is superior to the two methods usedalone.Conclusion: Full-term asphyxia children with HIE early after birth (within24h)serum NSE concentration significantly increased, and the middle cerebral arteryresistance index increased significantly, and full-term asphyxia of HIE patients andnormal full-term newborns have significant difference, compared to HIE earlyprediction and early intervention has a certain clinical significance; While detectingfull-term asphyxia neonates born at6h after12h after middle cerebral arteryresistance index and serum levels of NSE protein can improve the early diagnosis ofHIE predict specific degree, sensitivity, and lower false positive rate and falsenegative rate, and can provide the basis for HIE early diagnosis prediction, conduciveto the early intervention, to reduce sequelae, reduce mortality has importantsignificance. |
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