Analysis Of The Correlation Between Diabetes Mellitus And Thyroid Nodules

Objective: Diabetes and thyroid diseases are common diseases of endocrinesystem, the relationship between the two diseases has attracted attention of manyscholars, some scholars think, these two kinds of disease has a genetic andimmunological basis for common. At present about diabetes and the volume of thyroidor thyroid function, there are a lot of researches. The relationship between diabetes andthyroid nodules and the reason about possible research less, no conclusion has beenreached so far. This paper aims to study the correlation between diabetes and thyroidnodules, to investigate the effect of thyroid nodule formation reasons.Methods: The research object is the age of more than40years old, Daliancommunity residents who attended the "Cancer epidemiology research in patients withtype2diabetes of China " launched by the Chinese Medical Association during theAugust16and December10th in2011year, a total of10300cases. Except for theprevious operation history of thyroid, thyroid function hyperthyroidism, hypothyroidism,Hashimoto’s thyroiditis, thyroid disease and previous taking levothyroxine orantithyroid drug. The study object is the thyroid ultrasound showed normal thyroid andthyroid nodules, the research object eligible to collect a total of8178cases. The grouphas ruled out infection, diabetic ketoacidosis, hypoglycemia, electrolyte, acid-baseimbalance and serious heart, liver, kidney function impairment.Results:1.Subjects were divided into normal thyroid and thyroid nodule group,compared two groups of average data: a total of8178subjects,3689cases of normalgroup （45.1%）,4489cases of thyroid nodules group（54.9%）. Age, FPG,2hPG, BMI,waist circumference, LDL-C, TC, HbA1c, SBP of thyroid nodule group is higher thannormal group, the difference was statistically significant （P <0.05）,there is nostatistical significance difference between two groups in body weight, waist hip ratio, HDL-C, TG and DBP.2.Comparison the detection rate of thyroid nodules between male vs female.Detection of thyroid nodules in female are higher than that of male, the difference wasstatistically significant （58.4%vs45.7%, χ2=1.061, P=0.000）.3. Comparison of thyroid nodule detection rate between diabetic vs nondiabetic.Detection of thyroid nodules in diabetic population was higher than that in non-diabeticpopulation, the difference was statistically significant （59.3%vs52.5%, χ2=20.120,P=0.000）.4. The relationship between FPG,2hPG, HbA1c and thyroid nodules. FPG,2hPG,HbA1c is divided into two groups by7.0mmol/l,11.1mmol/l,6.5%respectively,compare the detection rate of thyroid nodule between two groups.（1）Compare detection rate of thyroid nodule between the two groups of FPG:detection rate of thyroid nodule in FPG≥7.0mmol/l group is higher than that of FPG <7.0mmol/l group, the difference was statistically significant （57.8%vs54.3%, χ2=5.997, P=0.014）.（2）Compare detection rate of thyroid nodule between the two groups of2hPG:detection rate of thyroid nodule in2hPG≥11.1mmol/l group is higher than that of2hPG <11.1mmol/l group, the difference was statistically significant（60.1%vs53.6%,χ2=21.884, P=0.000）.（3）Compare detection rate of thyroid nodule between the two groups of HbA1c:detection rate of thyroid nodule in HbA1c≥6.5%group is higher than that of HbA1c <6.5%group, the difference was statistically significant61.3%vs53.6%, χ2=27.921,P=0.000）.5. Screen independent risk factor of thyroid nodules（1） The relationship between diabetes and thyroid nodules: logistic regressionanalysis shows that, age （OR=1.042,95%CI:1.036-1.048, P=0.000）, gender（OR=1.995,95%CI:1.792-2.220, P=0.000）, BMI （OR=1.019,95%CI:1.000-1.038,P=0.049）, diabetes（OR=1.129,95%CI:1.011-1.261, P=0.032）can be entered into theregression equation.（2） The relationship between FPG,2hPG, HbA1c and thyroid nodules: age（OR=1.042,95%CI:1.036-1.048, P=0.000）, gender （OR=1.965,95%CI:1.764-2.188, P=0.000）, BMI （OR=1.019,95%CI:1.000-1.038, P=0.047） can be entered into theregression equation, FPG,2hPG, HbA1c does not enter the regression equation.Conclusion:1.Diabetes is an independent risk factor for thyroid nodules.2. Age, sex and body mass index are independent risk factors of thyroid nodules.