The Clinical Study Of Bushenyijing Formula On Mild-to-moderate Vascular Dementia

Objective:Explore the theoretical basis of vascular dementia from kidney essence deficiency, blood stasis theory.To observe the clinical efficacy of Bushenyijing formula on mild to moderate vascular dementia (VaD),with an aim for the nature of the pathological and law of vascular dementia syndrome to further understanding,so as to provide new ideas and more evidence based medicine for the clinical treatment of vascular dementia.Methods:The test followed randomized, controlled clinical trial design.According to the standard,60patients were selected and were randomly divided into a control group and the treatment group,30cases each.The patients of the control group were administered with the western medicine anlishen.The patient of the treatment group were administered with the herbal medicine Bushenyijing square.Both groups were continuous medication for12weeks for a course of treatment.Besides on the change of MMSE, ADAS-cog integral and TCM syndrome indicators, before and after treatment, discussing the clinical efficacy of the Bushenyijing side on remission of disease, improve cognitive function.Results:Patients in both groups with a total of60cases of non-shedding and eliminate casescompleted clinical trials.The Chinese medicine Bushenyijingformulaand anlishen both can improve the cognitive function in mild to moderate vascular dementia patients (P<0.05).Comprehensive curative effect:In the treatment group close out0cases, marked effective in7cases, effective in14cases, ineffective in9cases, deterioration0cases, the total effective rate was70.0%;in the control group, were0cases,3cases,16cases,11cases,0cases, the total effective rate was63.3%. Compare two sets of integrated efficacy by the rank-sum test, P>0.05, not statistically significant. Prompted two groups.May be related to the small sample size,and a shorter course of treatment. However, compared with the otal effective rate, the treatment group was significantly higher, suggesting that the treatment group have an advantage than the control group. Compared with before treatment,MMSE Points, ADAS-cog Points and symptom scores differences were significant after treatment (P<0.01,0.05).show that Bushenyijingformulahas significantly improve the role of cognitive function and clinical symptoms in patients with vascular dementia.The comparison between the two sets of MMSE Points, difference was not significant (P>0.05),However, the differencehere was a significant (P<0.05),The comparison between the two sets of ADAS-cog Points and symptoms scale difference was statistically significant (P <0.01,0.05).Compared with western medicine anlishen,the treatment of mild to moderate vascular dementia efficacy with Bushenyijingformulawas more bettre.There were no significant adversary reactions in Patients during the test process. The two methods were both safty.Conclusion:The treatment of mild to moderate vascular dementia with Bushenyijingformulahas a significant effect, and the application where better than western medicine anlishen,.no significant adverse reactions.