| Objective:Tian dijing pill treatment of vascular dementia(liver and kidney deficiency and fatigue resistance sputum Tongxinluo card)the clinical efficacy and safety of Tian Dijing pill provide a scientific basis for clinical application.Methods:1.By the spirit of the United States Institute of Neurology vascular dementia diagnostic criteria(DSM-Ⅳ),with simple mental state examination(MMSE),as well as general performance(Syndrome),the patient's consent with patients into the standard,included in the study of 90 cases,were randomly divided into treatment group(hereinafter referred to as Group A)60(hereinafter referred to as Group B)30 cases.2.Oral treatment group Tian Dijing pill three times daily,the control group oral tablets each time Xide two,three times a day,for a month.3.Patients were observed before and after the treatment of cognitive function, symptoms and related Chinese tongue,the changes in pulse,before treatment and after treatment records once every two weeks,completing the clinical observation periodic table.The main effect of indicators:mental state(MMSE),as well as general performance(Syndrome).4.Drugs before and after the general physical examination record(temperature, respiration,pulse,blood pressure),blood,urine,it conventional,heart,liver,kidney function,blood rheology,electrocardiogram,a security observation.Through testing before and after treatment with blood clotting function 10(PLT,RBC,Hb,WBC,N,L, PLT,APTT,PT),urine,feces conventional liver function(ALT),renal function(BUN, Cr),as well as ECG,and to observe the process of administration of the frequency of adverse events,as well as the incidence of drug and test the relevance of Tian Dijing pill treatment of vascular dementia(deficiency and liver and kidney sputum addiction resistance Tongxinluo Cards)security tolerance.5.Statistically:by t-test measurement data,the count data used x~2 test,grading information used Ridit analysisResults:1.A group treatment of vascular dementia(VD),the MMSE effect:basic control of six cases(10%),markedly effective in 28 cases(46.67%),effective 18 cases(30%), invalid eight cases(13.33%)and the overall efficiency 86.67%;Clinical Syndrome: clinical cure in 12 cases(20%),markedly effective in 22 cases(35.67%),effective 14 cases(23.33%),ineffective in 12 cases(20%),and the total efficiency of 80%.Group B treatment of vascular dementia,MMSE effect:one case of basic clinical control (3.3%),effectual nine cases(30%),effective eight cases(26.67%),ineffective in 12 cases(40%),and the total efficiency of 60%;Clinical Syndrome:Clinical recovered six cases(20%),effectual seven cases(23.33%),5 cases(16.67%),ineffective in 12 cases(40%),and the total efficiency of 60%.MMSE total effect between the two groups statistically,the difference was significant(P＜0.05)in the treatment group was significantly higher than that of the treatment group.Syndrome of the statistical treatment,there were significant differences(P＜0.05)higher than that of the treatment group therapy group.2.TCM-related symptoms on the total score compared with the group before treatment and after treatment with significant differences(P＜0.05),two groups of Chinese medicine after treatment symptom scores were significantly reduced after the end of a course of treatment symptom scores between the two groups more Chinese significant difference(P＜0.05),the treatment group was significantly less than the control group.3.Symptoms improved in the relevant Chinese medicine,Chinese medicine in the two groups of related symptoms after treatment than before treatment have significantly improved(P＜0.05),after the end of a course of treatment,TCM treatment group in improving symptoms was superior to the control group(P＜0.05).4.Tian Dijing pill treatment of vascular dementia(VD)on the gender,age,education and so on there was no significant difference on their extensive adaptation,but the length of the course,the degree of dementia and the number of complications There was a significant difference.Research shows that the short duration of the disease than patients with mild disease than patients with moderate conditions,the merger of the disease less than with multiple diseases.5.Safety Analysis:patient medication during the two found a allergies,medication before and after no significant changes in vital signs,medication before and after the two cases of blood,urine,feces conventional,liver,kidney function and ECG showed no change,there is no difference between the two groups was significant.Drugs before and after the blood rheology indicators clinical significance of the difference was not that Tian Dijing pill in the treatment of vascular dementia(VD)process no obvious side effects,safe,and reliable.Conclusion:Through the above analysis shows that Tian Dijing pill treatment of vascular dementia(VD)Clinical precise,can improve cognitive ability in patients with Chinese medicine and related symptoms,safe,reliable,and can improve the quality of life of patients for the treatment of vascular dementia effective drugs and one way. |
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