Soluble Triggering Myeloid Cell Receptor STERM-1in The Diagnosis Of Pulmonary Infection

Objective:Detect soluble myeloid cells triggered receptor-1(sTREM-1)、PCT、CRP inperipheral blood of patients with pulmonary infection， observe diagnosticsignificance of sTREM-1in pulmonary infection patients， find the differencebetween CAP and HAP and evaluate its clinical application value.Methods:Use ELISA to detect sTREM-1、PCT、CRP level in peripheral blood inexperimental group(including30cases of patients with CAP and18cases of HAPpatients) and control group(including14cases with diffuse pulmonary disease).Record expression of each index， and calculate sensitivity、specificity and accuracyof single detection or combined detection.Results:(1) Compare to the diffuse pulmonary disease group， the CAP group serumsTREM-1[（99.71±111.17）pg/ml]、PCT[（10.26±22.02）ug/ml] are much higher(P＜0.05) than the control group;(2) The HAP group serum sTREM-1[（117.40±134.73）pg/ml]、PCT[（8.67±9.11）ug/ml] are much higher(P＜0.05) than that in thediffuse pulmonary disease group;(3) There is no significant difference in sTREM-1、PCT、CRP between CAP and HAP group;(4) By the use of the ROC curve， the bestthreshold of serum sTREM-1is38.13pg/ml， in CAP group sensitivity is0.900andaccuracy is0.864， which are higher than PCT and CRP (P＜0.05); in HAP groupsensitivity is0.889and accuracy is0.844， which are higher than PCT and CRP(P＜0.05); specificity is0.786，no significant difference from PCT;(5) Both in CAP groupand HAP group the sensitivity、specificity and accuracy of diagnosis of sTREM-1+PCT are higher than single detection (P＜0.05).Conclusion:1. Serum sTREM-1、PCT and CRP level increase significantly both in CAP andHAP， the sensitivity、specificity and accuracy of sTREM-1and PCT are better thanCRP, the sensitivity and accuracy of sTREM-1are better than PCT; 2. The combined detection of sTREM-1and PCT can improve the sensitivity、specificity and accuracy in the diagnosis of CAP and HAP；3. There is no significant difference of serum sTREM-1、PCT and CRP levelboth in CAP group and HAP group.