Expression Of STREM-1 In Patients With Chronic Obstructive Pulmonary Disease

Objective:The aim was to investigate the concentration of sTREM-1 in peripheral blood and sputum from patients with chronic obstructive pulmonary disease,and to analyze the correlation between the sTREM-1 and the severity of chronic obstructive pulmonary disease.Methods:The concentration of sTREM-1 in peripheral blood and sputum were determined by ELISA in 12 acute exacerbation of COPD subjects,11 acute exacerbation of COPD subjects treated 2 weeks,17 stable COPD subjects,and 12 healthy individuals.The total and differential white cell counts,pulmonary function tests were performed at the same time.And the relationship between the concentration of sTREM-1 in sputum from patients with acute exacerbation of COPD and FEV₁ was analyzed. Results:The concentration of sTREM-1 in sputum from acute exacerbation of COPD group(243.65±86.42 pg/ml)and exacerbation of COPD subjects treated 2 weeks group(124.84±35.65pg/ml)had a significantly higher than the stable group(13.23±9.76 pg/ml),(P＜0.05).No significantly differences in the concentration of sTREM-1 were observed among the acute exacerbation of COPD group and exacerbation of COPD subjects treated 2 weeks.Comparison to control group(24.86±12.01pg/ml)in peripheral blood,the concentration of sTREM-1,acute exacerbation of COPD group(59.57±23.46pg/ml),acute exacerbation of COPD subjects treated 2 weeks group(31.43±25.81 pg/ml),the stable group(23.96±12.94 pg/ml)had no significantly differences.In acute exacerbation of COPD group,the concentration of sTREM-1 in sputum was significantly negative correlated with FEV₁%(r=-0.623,P＜0.05).Independent factor of the lung function by linear Regression(stepwise):the concentration of sTREM-1 in sputum with acute exacerbation of COPD was significantly negative correlated with FEV₁%,but Sex was positive correlated.Conclusion: The airway inflammation can be reflected by the concentration of sTREM-1 in sputum from patients with acute exacerbation of COPD,and the concentration of sTREM-1 may be a prognosis index of COPD,sTREM-1 seems to the standard of the therapy of airway inflammation in the future.On the contrary,it can not be reflected by the concentration of sTREM-1 in peripheral blood.