The Hs-CRP, Hcy, UMA Levels And Coronary Heart Disease Chronic Heart Failure TCM Syndrome Type Correlation Analysis And Discussion

Objective:To observe distributed characteristics and evolvement rule of chronic heartfailure patients with coronary heart disease(CHF&CAD) traditional Chinesemedicine(TCM) syndrome types.To discusse the correlation among the concentration ofhs-CRP, Hcy, UMA,cardiac function (NYHA classification) and TCM syndrome types, soas to make objective and quantitative diagnosis about TCM syndrome types, to provide anobjective basis about CHF&CAD TCM syndrome types.Methods:1.To collect70CHF&CAD patients and24CAD patients in Penglai city hospital ofTCM, who will be included in the test group and control group when they meet thediagnostic standard and except to exclude standard.2.Patients enrolled in this study will be took the median cubital vein blood which willbe used to determine the concentration of hs-CRP and Hcy after fasting more than12hoursin the next morning. To test UMA after specimens from the24-hoururine.Echocardiography, chest X-ray(lung CT), ECG, urinalysis, coagulation series, bloodlipids, blood glucose, liver and kidney functions will be checked to rule out organicdiseases and obvious functional diseases of the lung, liver, kidney and other organs.3.Complete the clinical data collection form and the data collation and statisticalanalysis.Results:1.The average heart function series of CHF&CAD five TCM syndrome types isdifferent and there are significant differences (P <0.01), the average grade size of each syndrome type is as follows: both Qi and Yin deficiency <Qi deficiency andbloodstasis<heart and kidney yang deficiency <phlegm blocking lung <yang deficiencywater generics, the average heart function of the five TCM syndrome types shows anincreasing trend.2.Hs-CRP and UMA concentration of CHF&CAD is significantly higher than CAD,with a significant difference (P <0.01). Hcy concentration of CHF&CAD and CAD wasstatistically significant (P <0.05).Three groups of patients with CHF&CAD cardiac function II-IV grade with hs-CRPand the UMA concentration has a significant difference (P <0.01), Hcy levels wasstatisstically significant(P <0.05), all increasing by cardiac function deterioration andshowing a significant positive correlation with cardiac function.3.There is no statistically significant about Hcy level of CHF&CAD different TCMsyndrome types. hs-CRP and UMA level of CHF&CAD different TCM syndrome typeshas significant difference (P <0.01), rising by the transformation of both Qi and Yindeficiency-Qi deficiency and blood stasis-heart and kidney yang deficiency-phlegmblocking lung-yang deficiency water generics.there is no significant correlation betweendifferent TCM syndromes of CHF&CAD and hs-CRP and UMA level by the Spearmancorrelation coefficient test.Conclusion:1.CHF&CAD TCM syndrome types distribution shows both Qi and Yindeficiency-Qi deficiency and blood stasis-heart and kidney yang deficiency-phlegmblocking lung-yang deficiency water generics by the increase of cardiac function series.2.The hs-CRP and UMA level of CHF&CAD is significantly higher than CAD, Hcylevels of statistical significance between the two groups, who is positively correlated withheart function classification,reflecting cardiac function. All were the reflections of theimportant indicators of CHF&CAD.3.Hs-CRP and UMA of CHF&CAD different TCM syndromes increased with thechange of both Qi and Yin deficiency-Qi deficiency and blood stasis-heart and kidney yangdeficiency-phlegm blocking lung-yang deficiency water generics,showing hs-CRP andthe UMA has a certain reference value. There is no obvious meaning between Hcy andCHF&CAD TCM syndrome types.